caa a22 4500 463249240 CHVBK 20180405153335.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s11130-007-0044-x doi (NATIONALLICENCE)springer-10.1007/s11130-007-0044-x Antioxidant and Antimutagenic Activities of Randia echinocarpa Fruit [Elektronische Daten] [María Santos-Cervantes, María Ibarra-Zazueta, Guadalupe Loarca-Piña, Octavio Paredes-López, Francisco Delgado-Vargas] We report for the first time the antioxidant and antimutagenic activities of fractions from Randia echinocarpa fruit, which is a Rubiaceae plant native to Sinaloa, Mexico. This fruit has been traditionally used in the prevention or treatment of cancer, among other diseases. The pulp of the fruit was sequentially extracted with solvents of different polarity (i.e. hexane, chloroform, methanol and water). A high extraction yield was obtained with methanol (72.17%d.w.). The aqueous extract showed the highest content of phenolics (2.27mg/g as ferulic acid equivalents) and the highest antioxidant activity based on the β-carotene bleaching method (486.15). The commercial antioxidant BHT was used as control (835.05). Antimutagenic activity of the aqueous extract (0-500μg/tube) was evaluated using the Salmonella microsuspension assay (YG1024 strain) and 1-NP as the mutagen (50 and 100ng/tube). The aqueous extract was neither toxic nor mutagenic and the percentage of inhibition on 1-NP mutagenicity was 32 and 53% at doses of 50 and 100ng/tube, respectively. The results of the double incubation assay suggest that the extract inhibited the mutagenicity of 1-NP by a combination of desmutagenic and bioantimutagenic effects. Springer Science+Business Media, Inc., 2007 Antimutagenic activity nationallicence Antioxidant activity nationallicence Desmutagen and bioantimutagen nationallicence Randia echinocarpa nationallicence Salmonella typhimurium nationallicence Total phenolics nationallicence Santos-Cervantes María Maestría en Ciencia y Tecnología de Alimentos, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010, Culiacán Sin., Mexico aut Ibarra-Zazueta María Maestría en Ciencia y Tecnología de Alimentos, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010, Culiacán Sin., Mexico aut Loarca-Piña Guadalupe PROPAC (Programa de Posgrado en Alimentos del Centro de la República), Research and Graduated Studies in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, 76010, Querétaro Qro., México aut Paredes-López Octavio Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500, Irapuato Gto., Mexico aut Delgado-Vargas Francisco Maestría en Ciencia y Tecnología de Alimentos, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010, Culiacán Sin., Mexico aut Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/2(2007-06-01), 71-77 0921-9668 62:2<71 2007 62 11130 https://doi.org/10.1007/s11130-007-0044-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11130-007-0044-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Santos-Cervantes María Maestría en Ciencia y Tecnología de Alimentos, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010, Culiacán Sin., Mexico aut NATIONALLICENCE 700 1- Ibarra-Zazueta María Maestría en Ciencia y Tecnología de Alimentos, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010, Culiacán Sin., Mexico aut NATIONALLICENCE 700 1- Loarca-Piña Guadalupe PROPAC (Programa de Posgrado en Alimentos del Centro de la República), Research and Graduated Studies in Food Science, School of Chemistry, Universidad Autónoma de Querétaro, 76010, Querétaro Qro., México aut NATIONALLICENCE 700 1- Paredes-López Octavio Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500, Irapuato Gto., Mexico aut NATIONALLICENCE 700 1- Delgado-Vargas Francisco Maestría en Ciencia y Tecnología de Alimentos, Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, 80010, Culiacán Sin., Mexico aut NATIONALLICENCE 773 0- Plant Foods for Human Nutrition Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 62/2(2007-06-01), 71-77 0921-9668 62:2<71 2007 62 11130 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer