caa a22 4500 463249291 CHVBK 20180405153335.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s10803-006-0328-2 doi (NATIONALLICENCE)springer-10.1007/s10803-006-0328-2 A Prospective Case Series of High-risk Infants who Developed Autism [Elektronische Daten] [Susan Bryson, Lonnie Zwaigenbaum, Jessica Brian, Wendy Roberts, Peter Szatmari, Vicki Rombough, Catherine McDermott] The present paper documents the development of autism/autistic spectrum disorder in a consecutive series of nine high-risk infants followed prospectively from 6months of age. Evidence is provided for two broadly defined subgroups: the first subgroup (n=6) showed a decrease in IQ between 12 and 24 or 36months (from average/near average to severe cognitive impairment), whereas the second subgroup (n=3) continued to obtain average or near average IQs. Signs of autism emerged and/or were more striking earlier in the first subgroup. In all nine children, early impairment in social-communicative development coexisted with atypical sensory and/or motor behaviors, as did a temperamental profile marked by irritability/distress and dysregulated state. Discussion focuses on issues raised by the pattern of findings. Springer Science+Business Media, LLC, 2006 Autism nationallicence Phenotype nationallicence Early development nationallicence Social nationallicence Communication nationallicence Cognitive nationallicence Sensory nationallicence Motor nationallicence Temperament nationallicence High-risk infants nationallicence Bryson Susan Autism Research Centre, IWK Health Centre, Dalhousie University, 5850 University Avenue, B3K 6R8, Halifax, NS, Canada aut Zwaigenbaum Lonnie Child Psychiatry, Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada aut Brian Jessica Bloorview Kids Rehab, Toronto, ON, Canada aut Roberts Wendy Bloorview Kids Rehab, Toronto, ON, Canada aut Szatmari Peter Child Psychiatry, Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada aut Rombough Vicki North York General Hospital, Toronto, ON, Canada aut McDermott Catherine York University, Toronto, ON, Canada aut Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/1(2007-01-01), 12-24 0162-3257 37:1<12 2007 37 10803 https://doi.org/10.1007/s10803-006-0328-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10803-006-0328-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bryson Susan Autism Research Centre, IWK Health Centre, Dalhousie University, 5850 University Avenue, B3K 6R8, Halifax, NS, Canada aut NATIONALLICENCE 700 1- Zwaigenbaum Lonnie Child Psychiatry, Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Brian Jessica Bloorview Kids Rehab, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Roberts Wendy Bloorview Kids Rehab, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Szatmari Peter Child Psychiatry, Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Rombough Vicki North York General Hospital, Toronto, ON, Canada aut NATIONALLICENCE 700 1- McDermott Catherine York University, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/1(2007-01-01), 12-24 0162-3257 37:1<12 2007 37 10803 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer