caa a22 4500 463250087 CHVBK 20180405153337.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10803-006-0179-x doi (NATIONALLICENCE)springer-10.1007/s10803-006-0179-x Studying the Emergence of Autism Spectrum Disorders in High-risk Infants: Methodological and Practical Issues [Elektronische Daten] [Lonnie Zwaigenbaum, Audrey Thurm, Wendy Stone, Grace Baranek, Susan Bryson, Jana Iverson, Alice Kau, Ami Klin, Cathy Lord, Rebecca Landa, Sally Rogers, Marian Sigman] Detecting early signs of autism is essential for timely diagnosis and initiation of effective interventions. Several research groups have initiated prospective studies of high-risk populations including infant siblings, to systematically collect data on early signs within a longitudinal design. Despite the potential advantages of prospective studies of young children at high-risk for autism, there are also significant methodological, ethical and practical challenges. This paper outlines several of these challenges, including those related to sampling (e.g., defining appropriate comparison groups), measurement and clinical implications (e.g., addressing the needs of infants suspected of having early signs). We suggest possible design and implementation strategies to address these various challenges, based on current research efforts in the field and previous studies involving high-risk populations. Springer Science+Business Media, Inc., 2006 Early identification nationallicence Screening nationallicence Longitudinal studies nationallicence Prospective studies nationallicence Infant nationallicence Autism nationallicence Child development nationallicence Siblings nationallicence Zwaigenbaum Lonnie Department of Paediatrics, McMaster Children's Hospital at McMaster University, PO Box 2000, L8N 3Z5, Hamilton, Ontario, Canada aut Thurm Audrey Division of Pediatric Translational Research and Treatment Development, National Institute of Mental Health, Bethesda, MD, USA aut Stone Wendy Departments of Pediatrics and Psychology & Human Development, Vanderbilt University, Nashville, TN, USA aut Baranek Grace Division of Occupational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut Bryson Susan Departments of Pediatrics and Psychology, Dalhousie University, Halifax, NS, USA aut Iverson Jana Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA aut Kau Alice Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, Bethesda, MD, USA aut Klin Ami Yale Child Study Centre, Yale University, New Haven, CT, USA aut Lord Cathy Department of Psychology, University of Michigan, Ann Arbor, MI, USA aut Landa Rebecca Department of Psychiatry and Behavioral Sciences, Kennedy Krieger Institute, Baltimore, MD, USA aut Rogers Sally Department of Psychiatry and Behavioral Sciences, University of California at Davis, Sacramento, CA, USA aut Sigman Marian Departments of Psychology and Psychiatry, University of California, Los Angeles, CA, USA aut Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/3(2007-03-01), 466-480 0162-3257 37:3<466 2007 37 10803 https://doi.org/10.1007/s10803-006-0179-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10803-006-0179-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zwaigenbaum Lonnie Department of Paediatrics, McMaster Children's Hospital at McMaster University, PO Box 2000, L8N 3Z5, Hamilton, Ontario, Canada aut NATIONALLICENCE 700 1- Thurm Audrey Division of Pediatric Translational Research and Treatment Development, National Institute of Mental Health, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Stone Wendy Departments of Pediatrics and Psychology & Human Development, Vanderbilt University, Nashville, TN, USA aut NATIONALLICENCE 700 1- Baranek Grace Division of Occupational Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Bryson Susan Departments of Pediatrics and Psychology, Dalhousie University, Halifax, NS, USA aut NATIONALLICENCE 700 1- Iverson Jana Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Kau Alice Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development, Bethesda, MD, USA aut NATIONALLICENCE 700 1- Klin Ami Yale Child Study Centre, Yale University, New Haven, CT, USA aut NATIONALLICENCE 700 1- Lord Cathy Department of Psychology, University of Michigan, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Landa Rebecca Department of Psychiatry and Behavioral Sciences, Kennedy Krieger Institute, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Rogers Sally Department of Psychiatry and Behavioral Sciences, University of California at Davis, Sacramento, CA, USA aut NATIONALLICENCE 700 1- Sigman Marian Departments of Psychology and Psychiatry, University of California, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/3(2007-03-01), 466-480 0162-3257 37:3<466 2007 37 10803 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer