caa a22 4500 463250125 CHVBK 20180405153337.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s10803-006-0182-2 doi (NATIONALLICENCE)springer-10.1007/s10803-006-0182-2 Quantitative Assessment of Autism Symptom-related Traits in Probands and Parents: Broader Phenotype Autism Symptom Scale [Elektronische Daten] [Geraldine Dawson, Annette Estes, Jeffrey Munson, Gerard Schellenberg, Raphael Bernier, Robert Abbott] Autism susceptibility genes likely have effects on continuously distributed autism-related traits, yet few measures of such traits exist. The Broader Phenotype Autism Symptom Scale (BPASS), developed for use with affected children and family members, measures social motivation, social expressiveness, conversational skills, and flexibility. Based on 201 multiplex families, psychometric data on the BPASS are reported. Adequate inter-rater reliability and internal consistency were found. Parents had lower BPASS scores than affected children, after controlling for IQ. Parents and affected children showed overlapping distributions suggesting the BPASS captured variability in traits across groups. BPASS scores were not correlated with ethnicity or parent education; however, some domains were correlated with IQ. The BPASS holds promise as a quantitative phenotypic assessment for genetic studies. Springer Science+Business Media, Inc., 2006 Broader phenotype nationallicence Genetics nationallicence Quantitative traits nationallicence Autism nationallicence Dawson Geraldine University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut Estes Annette University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut Munson Jeffrey University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut Schellenberg Gerard Veterans Affairs Medical Center, Seattle; Departments of Medicine, Neurology and Pharmacology, University of Washington, Seattle, WA, USA aut Bernier Raphael University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut Abbott Robert Department of Educational Psychology, University of Washington, Seattle, WA, USA aut Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/3(2007-03-01), 523-536 0162-3257 37:3<523 2007 37 10803 https://doi.org/10.1007/s10803-006-0182-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10803-006-0182-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dawson Geraldine University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Estes Annette University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Munson Jeffrey University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Schellenberg Gerard Veterans Affairs Medical Center, Seattle; Departments of Medicine, Neurology and Pharmacology, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 700 1- Bernier Raphael University of Washington Autism Center and Department of Psychology, University of Washington, Box 357920, 98195, Seattle, WA, USA aut NATIONALLICENCE 700 1- Abbott Robert Department of Educational Psychology, University of Washington, Seattle, WA, USA aut NATIONALLICENCE 773 0- Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/3(2007-03-01), 523-536 0162-3257 37:3<523 2007 37 10803 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer