caa a22 4500 463250478 CHVBK 20180405153338.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10803-006-0324-6 doi (NATIONALLICENCE)springer-10.1007/s10803-006-0324-6 Hyperserotonemia in Adults with Autistic Disorder [Elektronische Daten] [Dubravka Hranilovic, Zorana Bujas-Petkovic, Renata Vragovic, Tomislav Vuk, Karlo Hock, Branimir Jernej] Hyperserotonemia is the most consistent serotonin-related finding in autism. The basis of this phenomenon, and its relationship to the central serotonergic dysfunction remains unclear. Platelet serotonin level (PSL) in 53 autistic adults and 45 healthy controls was measured. Mean PSL in autistic group (75.7±37.4ng/μL) was significantly higher than the control sample (59.2±16.2ng/μL) due to a presence of hyperserotonemic subjects which comprised 32% of the patients. PSL of autistic subjects did not correlate with the severity of symptoms, as measured by total CARS score, or the degree of mental retardation. However, significant negative relationship was observed between PSL and speech development, indicating the relationship between the peripheral 5HT concentrations and verbal abilities in autistic subjects. Springer Science+Business Media, LLC, 2006 Autism nationallicence Hyperserotonemia nationallicence Platelet serotonin level nationallicence Speech development nationallicence Verbal communication nationallicence Hranilovic Dubravka Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000, Zagreb, Croatia aut Bujas-Petkovic Zorana Psychiatric Hospital for Children and Youth, Kukuljeviceva 15, 10 000, Zagreb, Croatia aut Vragovic Renata Center for autism Zagreb, Dvorniciceva 11, 10 000, Zagreb, Croatia aut Vuk Tomislav Croatian Institute of Transfusion Medicine, Petrova 3, 10 000, Zagreb, Croatia aut Hock Karlo Department of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10 000, Zagreb, Croatia aut Jernej Branimir Department of Molecular Biology, Rudjer Boskovic Institute, Bijenicka 54, 10 000, Zagreb, Croatia aut Journal of Autism and Developmental Disorders Springer US; http://www.springer-ny.com 37/10(2007-11-01), 1934-1940 0162-3257 37:10<1934 2007 37 10803 https://doi.org/10.1007/s10803-006-0324-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10803-006-0324-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hranilovic Dubravka Department of Animal Physiology, Faculty of Science, University of Zagreb, Rooseveltov trg 6, 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Bujas-Petkovic Zorana Psychiatric Hospital for Children and Youth, Kukuljeviceva 15, 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Vragovic Renata Center for autism Zagreb, Dvorniciceva 11, 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Vuk Tomislav Croatian Institute of Transfusion Medicine, Petrova 3, 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Hock Karlo Department of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka 54, 10 000, Zagreb, Croatia aut NATIONALLICENCE 700 1- Jernej Branimir Department of Molecular Biology, Rudjer Boskovic Institute, Bijenicka 54, 10 000, Zagreb, Croatia aut NATIONALLICENCE 773 0- Journal of Autism and Developmental Disorders Springer US; http://www.springer-ny.com 37/10(2007-11-01), 1934-1940 0162-3257 37:10<1934 2007 37 10803 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer