caa a22 4500 463250850 CHVBK 20180405153339.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10803-006-0271-2 doi (NATIONALLICENCE)springer-10.1007/s10803-006-0271-2 Processing of Affective Speech Prosody is Impaired in Asperger Syndrome [Elektronische Daten] [Pirjo Korpilahti, Eira Jansson-Verkasalo, Marja-Leena Mattila, Sanna Kuusikko, Kalervo Suominen, Seppo Rytky, David Pauls, Irma Moilanen] Many people with the diagnosis of Asperger syndrome (AS) show poorly developed skills in understanding emotional messages. The present study addressed discrimination of speech prosody in children with AS at neurophysiological level. Detection of affective prosody was investigated in one-word utterances as indexed by the N1 and the mismatch negativity (MMN) of auditory event-related potentials (ERPs). Data from fourteen boys with AS were compared with those for thirteen typically developed boys. These results suggest atypical neural responses to affective prosody in children with AS and their fathers, especially over the RH, and that this impairment can already be seen at low-level information processes. Our results provide evidence for familial patterns of abnormal auditory brain reactions to prosodic features of speech. Springer Science+Business Media, LLC, 2006 Asperger syndrome nationallicence Auditory perception nationallicence Affective prosody nationallicence Familial pattern nationallicence ERP nationallicence Korpilahti Pirjo Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut Jansson-Verkasalo Eira Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut Mattila Marja-Leena Department of Child Psychiatry, Oulu University Hospital, Oulu, Finland aut Kuusikko Sanna Department of Child Psychiatry, Oulu University Hospital, Oulu, Finland aut Suominen Kalervo Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut Rytky Seppo Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut Pauls David Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA aut Moilanen Irma Department of Child Psychiatry, Oulu University Hospital, Oulu, Finland aut Journal of Autism and Developmental Disorders Springer US; http://www.springer-ny.com 37/8(2007-09-01), 1539-1549 0162-3257 37:8<1539 2007 37 10803 https://doi.org/10.1007/s10803-006-0271-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10803-006-0271-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Korpilahti Pirjo Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut NATIONALLICENCE 700 1- Jansson-Verkasalo Eira Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut NATIONALLICENCE 700 1- Mattila Marja-Leena Department of Child Psychiatry, Oulu University Hospital, Oulu, Finland aut NATIONALLICENCE 700 1- Kuusikko Sanna Department of Child Psychiatry, Oulu University Hospital, Oulu, Finland aut NATIONALLICENCE 700 1- Suominen Kalervo Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut NATIONALLICENCE 700 1- Rytky Seppo Cognitive Laboratory, Clinical Neurophysiology, Oulu University Hospital, Oulu, Finland aut NATIONALLICENCE 700 1- Pauls David Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA aut NATIONALLICENCE 700 1- Moilanen Irma Department of Child Psychiatry, Oulu University Hospital, Oulu, Finland aut NATIONALLICENCE 773 0- Journal of Autism and Developmental Disorders Springer US; http://www.springer-ny.com 37/8(2007-09-01), 1539-1549 0162-3257 37:8<1539 2007 37 10803 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer