caa a22 4500 463250931 CHVBK 20180405153339.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10803-006-0226-7 doi (NATIONALLICENCE)springer-10.1007/s10803-006-0226-7 [3H]-Flunitrazepam-labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study [Elektronische Daten] [Jeffrey Guptill, Anne Booker, Terrell Gibbs, Thomas Kemper, Margaret Bauman, Gene Blatt] Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [3H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B max) or altered affinity (K d) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B max indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K d values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABAA receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. Springer Science+Business Media, LLC, 2006 Developmental disorder nationallicence Autoradiography nationallicence Hippocampus nationallicence GABAergic receptors nationallicence Hippocampal circuitry nationallicence Guptill Jeffrey Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut Booker Anne Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut Gibbs Terrell Department of Pharmacology and Therapeutics, Boston University School of Medicine, Boston, MA, USA aut Kemper Thomas Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut Bauman Margaret Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut Blatt Gene Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/5(2007-05-01), 911-920 0162-3257 37:5<911 2007 37 10803 https://doi.org/10.1007/s10803-006-0226-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10803-006-0226-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Guptill Jeffrey Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Booker Anne Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Gibbs Terrell Department of Pharmacology and Therapeutics, Boston University School of Medicine, Boston, MA, USA aut NATIONALLICENCE 700 1- Kemper Thomas Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Bauman Margaret Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut NATIONALLICENCE 700 1- Blatt Gene Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, R-1003, 02118, Boston, MA, USA aut NATIONALLICENCE 773 0- Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/5(2007-05-01), 911-920 0162-3257 37:5<911 2007 37 10803 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer