caa a22 4500 463251121 CHVBK 20180405153340.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10803-006-0150-x doi (NATIONALLICENCE)springer-10.1007/s10803-006-0150-x Brief Report: Identical Male Twins Concordant for Asperger's Disorder [Elektronische Daten] [Michiko Ishijima, Hiroshi Kurita] The first case study of identical male twins concordant for DSM-IV Asperger's disorder (ASD) was presented. Their monozygocity was confirmed by short tandem repeat analyses with a probability of 99.999963%. Despite sharing the same DNA and environment, the twins are different in comorbidity (i.e., major depressive disorder in the elder and absence seizure in the younger) and in IQs and motor performance (i.e., the elder was lower in IQs and clumsier). Both of them were normal in computed tomographic scanning and magnetic resonance imaging discordant with some previous reports of brain imaging abnormalities in ASD. Further studies are needed to clarify inherited/acquired epigenetic defects and brain imaging abnormalities relating to behavioral phenotypes in ASD twins. Springer Science+Business Media, Inc., 2006 Asperger's disorder nationallicence Comorbidity nationallicence Genetics nationallicence Monozygotic twins nationallicence Pervasive developmental disorders nationallicence Ishijima Michiko Department of Neuropsychiatry, University of Tokyo Medical Center, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut Kurita Hiroshi Zenkoku Ryoiku-Sodan Center, Tokyo, Japan aut Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/2(2007-02-01), 386-389 0162-3257 37:2<386 2007 37 10803 https://doi.org/10.1007/s10803-006-0150-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10803-006-0150-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishijima Michiko Department of Neuropsychiatry, University of Tokyo Medical Center, 7-3-1 Hongo, 113-8655, Bunkyo-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Kurita Hiroshi Zenkoku Ryoiku-Sodan Center, Tokyo, Japan aut NATIONALLICENCE 773 0- Journal of Autism and Developmental Disorders Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 37/2(2007-02-01), 386-389 0162-3257 37:2<386 2007 37 10803 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer