caa a22 4500 463253418 CHVBK 20180405153347.0 cr unu---uuuuu 170326e20071001xx s 000 0 eng 10.1007/s10562-007-9173-y doi (NATIONALLICENCE)springer-10.1007/s10562-007-9173-y An Environmentally Friendly Route for the Synthesis of Benzofurane Derivatives using Selective Ring Acylation of Resorcinol [Elektronische Daten] [Sándor Békássy, Béla Ágai, János Farkas, Eszter Gábor, Mária Ferenczi, François Figueras] The synthesis of 2,2-dimethyl-2,3-dihydro-benzofuran-6-ol, an important intermediate for benzofurane derivatives having pharmaceutical activity, is achieved by an environmentally friendly pathway. Whereas the current synthesis method, based on resorcinol dimethylether, uses or produces harmful, corrosive and dangerous reagents/materials, the procedure proposed here achieves 60% preparative yield for the selective direct ring acylation of resorcinol with isobutyryl chloride, using a solvent-free reaction catalysed by solid acids. Springer Science+Business Media, LLC, 2007 Clays nationallicence Acylation nationallicence Resorcinol nationallicence Solvent-free reaction nationallicence Benzofurane precursor nationallicence Békássy Sándor Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut Ágai Béla Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut Farkas János Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut Gábor Eszter Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut Ferenczi Mária Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut Figueras François Institut de Recherches sur la Catalyse, 2 Av. Albert Einstein, 69626, Villeurbanne, France aut Catalysis Letters Springer US; http://www.springer-ny.com 118/3-4(2007-10-01), 219-223 1011-372X 118:3-4<219 2007 118 10562 https://doi.org/10.1007/s10562-007-9173-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10562-007-9173-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Békássy Sándor Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut NATIONALLICENCE 700 1- Ágai Béla Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut NATIONALLICENCE 700 1- Farkas János Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut NATIONALLICENCE 700 1- Gábor Eszter Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut NATIONALLICENCE 700 1- Ferenczi Mária Department of Organic Chemical Technology, Budapest University of Technology and Economics, 1521, Budapest, Hungary aut NATIONALLICENCE 700 1- Figueras François Institut de Recherches sur la Catalyse, 2 Av. Albert Einstein, 69626, Villeurbanne, France aut NATIONALLICENCE 773 0- Catalysis Letters Springer US; http://www.springer-ny.com 118/3-4(2007-10-01), 219-223 1011-372X 118:3-4<219 2007 118 10562 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer