caa a22 4500 463254066 CHVBK 20180405153349.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s10571-006-9110-4 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9110-4 Influence of Acute and Chronic Treadmill Exercise on Rat Plasma Lactate and Brain NPY, L-ENK, DYN A1-13 [Elektronische Daten] [Jia-Xu Chen, Xin Zhao, Guang-Xin Yue, Zhu-Feng Wang] SUMMARY: This study was designed to investigate the effect of acute and chronic high-intensity treadmill exercise on changes in plasma lactate and brain neuropeptide (NPY), leucine-enkephalin (L-ENK), and dynorpin A1-13 (DYN A1-13). Avidin-biotin complex (ABC) immunohistochemistry and image pattern analysis were used to observe the effect of chronic (total 7 weeks) and acute treadmill exercise (an initial speed of 15mmin−1 gradually increased to 35mmin−1 with 0°, 20-25min per day duration) on the changes of NPY, L-ENK, and DYN A1-13 in different areas of rat brain. Plasma lactate was also measured in response to such exercise. Compared with preexercise control (P < 0.01), plasma lactate concentration significantly increased in the immediate postexercise; but it returned to the normal level soon after the 30min postexercise. The content of NPY in paraventricular (PVN), dorsomedial (DMN), and ventromedial (VMN) hypothalamic nuclei continued to increase in 0, 30, and 180min postexercise compared with preexercise control (P < 0.01). The content of L-ENK in caudate-putamen (CPu) significantly increased in the immediate postexercise compared with preexercise control (P < 0.01), but it gradually returned to the normal level after the 180min postexercise. However, the content of DYN A1-13 in PVN rose substantially only in 30min postexercise in comparison with the preexercise control (P < 0.01). Thus, different changes of NPY, L-ENK, and DYN A1-13 in response to such high-intensity exercise depend on the brain region and the time examined, especially, the contents of NPY in different brain regions continuously remain at a high level after such high-intensity exercise. And this high level might reduce energy expenditure and thus contribute to the stimulation of brain NPY neurons. Springer Science+Business Media, Inc., 2006 exercise nationallicence lactate nationallicence neuropeptide Y nationallicence leucine-enkephalin nationallicence dynorphin A1-13 nationallicence Chen Jia-Xu Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut Zhao Xin Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut Yue Guang-Xin Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut Wang Zhu-Feng Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/1(2007-01-01), 1-10 0272-4340 27:1<1 2007 27 10571 https://doi.org/10.1007/s10571-006-9110-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9110-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Jia-Xu Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Zhao Xin Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Yue Guang-Xin Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Zhu-Feng Department of TCM Diagnosis, Beijing University of Traditional Chinese Medicine, No. 11, Beisanhuan Donglu, Chaoyang District, 100029, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/1(2007-01-01), 1-10 0272-4340 27:1<1 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer