caa a22 4500 463254112 CHVBK 20180405153349.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s10571-006-9119-8 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9119-8 Genetic Manipulation of Neural Stem Cells for Transplantation into the Injured Spinal Cord [Elektronische Daten] [Bor Luen Tang, Choon Bing Low] The injured adult spinal cord is not conducive for neuronal regeneration and neurogenesis. Engrafted neural precursor cells (NPCs) differentiate largely into astroglia, with only a very small percentage becoming neurons (which might replace injured neurons) or oligodendroglia (which might improve injury induced demyelination of spared neurons). Several recent attempts have been made to enhanced neurogenesis or oligodendroglia differentiation of transplanted NPCs by genetic manipulation. These include exogenous expression of noggin, with the idea of antagonizing the astroglia differentiation promoting Bone Morphogenetic Proteins (BMPs). Direct attempts to enhance neurogenesis have also been made in transgenic over-expression of neurogenic basic helix-loop-helix transcription factors. These experiments resulted in some interesting observations, which we discuss here in the light of recent advances in development of cell-based engraftment therapy for spinal cord injuries. Springer Science+Business Media, LLC, 2006 bone morphogenetic proteins (BMPs) nationallicence neural progenitor cells nationallicence neurogenin nationallicence noggin nationallicence spinal cord injury (SCI) nationallicence Tang Bor Luen Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Garden City, Singapore aut Low Choon Bing Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Garden City, Singapore aut Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/1(2007-01-01), 75-85 0272-4340 27:1<75 2007 27 10571 https://doi.org/10.1007/s10571-006-9119-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9119-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tang Bor Luen Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Garden City, Singapore aut NATIONALLICENCE 700 1- Low Choon Bing Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Garden City, Singapore aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/1(2007-01-01), 75-85 0272-4340 27:1<75 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer