caa a22 4500 463254244 CHVBK 20180405153349.0 cr unu---uuuuu 170326e20070901xx s 000 0 eng 10.1007/s10571-007-9159-8 doi (NATIONALLICENCE)springer-10.1007/s10571-007-9159-8 Immunohistological Determination of Ecto-nucleoside Triphosphate Diphosphohydrolase1 (NTPDase1) and 5′-nucleotidase in Rat Hippocampus Reveals Overlapping Distribution [Elektronische Daten] [Ivana Bjelobaba, Mirjana Stojiljkovic, Sanja Pekovic, Sanja Dacic, Irena Lavrnja, Danijela Stojkov, Ljubisav Rakic, Nadezda Nedeljkovic] Distribution of two enzymes involved in the ectonucleotidase enzyme chain, ecto-nucleoside triphosphate diphosphohydrolase1 (NTPDase1) and ecto-5′-nucleotidase, was assessed by immunohistochemistry in the rat hippocampus. Obtained results have shown co-expression of the enzymes in the hippocampal region, as well as wide and strikingly similar cellular distribution. Both enzymes were expressed at the surface of pyramidal neurons in the CA1 and CA2 sections, while cells in the CA3 section were faintly stained. The granule cell layer of the dentate gyrus was moderately stained for NTPDase1, as well as for ecto-5′-nucleotidase. Glial association for ecto-5′-nucleotidase was also observed, and fiber tracts were intensively stained for both enzymes. This is the first comparative study of NTPDase1 and ecto-5′-nucleotidase distribution in the rat hippocampus. Obtained results suggest that the broad overlapping distribution of these enzymes in neurons and glial cells reflects the functional importance of ectonucleotidase actions in the nervous system. Springer Science+Business Media, LLC, 2007 CD39 nationallicence CD73 nationallicence Ectonucleotidase nationallicence Extracellular nucleotides nationallicence Immunohistochemistry nationallicence Bjelobaba Ivana Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut Stojiljkovic Mirjana Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut Pekovic Sanja Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut Dacic Sanja Institute of Physiology and Biochemistry, Faculty of Biology, University Belgrade, Studentski trg 3, 11001, Belgrade, Serbia aut Lavrnja Irena Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut Stojkov Danijela Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut Rakic Ljubisav Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut Nedeljkovic Nadezda Institute of Physiology and Biochemistry, Faculty of Biology, University Belgrade, Studentski trg 3, 11001, Belgrade, Serbia aut Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/6(2007-09-01), 731-743 0272-4340 27:6<731 2007 27 10571 https://doi.org/10.1007/s10571-007-9159-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-007-9159-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bjelobaba Ivana Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut NATIONALLICENCE 700 1- Stojiljkovic Mirjana Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut NATIONALLICENCE 700 1- Pekovic Sanja Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut NATIONALLICENCE 700 1- Dacic Sanja Institute of Physiology and Biochemistry, Faculty of Biology, University Belgrade, Studentski trg 3, 11001, Belgrade, Serbia aut NATIONALLICENCE 700 1- Lavrnja Irena Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut NATIONALLICENCE 700 1- Stojkov Danijela Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut NATIONALLICENCE 700 1- Rakic Ljubisav Department of Neurochemistry and Immunonology, Institute for Biological Research "Sinisa Stankovic”, Belgrade, Serbia aut NATIONALLICENCE 700 1- Nedeljkovic Nadezda Institute of Physiology and Biochemistry, Faculty of Biology, University Belgrade, Studentski trg 3, 11001, Belgrade, Serbia aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/6(2007-09-01), 731-743 0272-4340 27:6<731 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer