caa a22 4500 463254333 CHVBK 20180405153350.0 cr unu---uuuuu 170326e20071101xx s 000 0 eng 10.1007/s10571-007-9208-3 doi (NATIONALLICENCE)springer-10.1007/s10571-007-9208-3 Mladinic Miranda Department of Neurobiology, SISSA Trieste, AREA Science Park, Strada Statale 14 km 163,5, 34012, Basovizza, Trieste, Italy aut Changes in Cyclic AMP Levels in the Developing Opossum Spinal Cord at the Time When Regeneration Stops Being Possible [Elektronische Daten] [Miranda Mladinic] Cyclic AMP (cAMP) is an important second messenger in signaling pathways that regulate cellular processes involved in development and regeneration. The changes in cAMP content of opossum spinal cords have been studied during the critical period of development, when the ability to regenerate axons after injury is lost. Endogenous cAMP levels were measured in tissue homogenates, and cAMP immunoreactivity was displayed in sections of lesioned and non-lesioned opossum P6 (can regenerate) and P13 (cannot regenerate) spinal cords. There was a significant decrease of the cAMP levels during the period critical for regeneration, while the level of cAMP was increased in P6 spinal cords after injury. Moreover, 5mM db-cAMP induced growth invitro of the injured axons in the spinal cord that has lost the capacity to regenerate. Springer Science+Business Media, LLC, 2007 Spinal cord nationallicence Opossum nationallicence cAMP nationallicence Regeneration nationallicence Development nationallicence Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/7(2007-11-01), 883-888 0272-4340 27:7<883 2007 27 10571 https://doi.org/10.1007/s10571-007-9208-3 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-007-9208-3 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Mladinic Miranda Department of Neurobiology, SISSA Trieste, AREA Science Park, Strada Statale 14 km 163,5, 34012, Basovizza, Trieste, Italy aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/7(2007-11-01), 883-888 0272-4340 27:7<883 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer