caa a22 4500 463254422 CHVBK 20180405153350.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10571-006-9122-0 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9122-0 Chelating Compound, Chrysoidine, Is More Effective in Both Antiprion Activity and Brain Endothelial Permeability Than Quinacrine [Elektronische Daten] [Katsumi Doh-ura, Kazuhiko Tamura, Yoshiharu Karube, Mikihiko Naito, Takashi Tsuruo, Yasufumi Kataoka] : 1. As an extension of our previous study of quinacrine and its derivatives, chelating chemicals were screened to obtain more effective, better brain-permeable antiprion compounds using either prion-infected neuroblastoma cells or brain capillary endothelial cells. 2. Eleven chemicals were found to have antiprion activity. Most of them shared a common structure consisting of benzene or naphthalene at either end of an azo bond. Structure-activity data suggest that chelating activity is not necessary but might contribute to the antiprion action. 3. Chrysoidine, a representative compound found here, was about 27 times more effective in the antiprion activity and five times more efficiently permeable through the brain capillary endothelial cells than quinacrine was. 4. These chemicals might be useful as compounds for development of therapeutics for prion diseases. Springer Science+Business Media, LLC, 2007 prion nationallicence chrysoidine nationallicence blood-brain barrier nationallicence aromatic azo compounds nationallicence therapy nationallicence chelating agents nationallicence brain endothelial cells nationallicence prion-infected neuroblastoma cells nationallicence Doh-ura Katsumi Department of Prion Research, Tohoku University Graduate School of Medicine, Sendai, Japan aut Tamura Kazuhiko Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan aut Karube Yoshiharu Department of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan aut Naito Mikihiko Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan aut Tsuruo Takashi Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan aut Kataoka Yasufumi Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan aut Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/3(2007-05-01), 303-316 0272-4340 27:3<303 2007 27 10571 https://doi.org/10.1007/s10571-006-9122-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9122-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Doh-ura Katsumi Department of Prion Research, Tohoku University Graduate School of Medicine, Sendai, Japan aut NATIONALLICENCE 700 1- Tamura Kazuhiko Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Karube Yoshiharu Department of Drug Design and Drug Delivery, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Naito Mikihiko Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsuruo Takashi Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kataoka Yasufumi Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/3(2007-05-01), 303-316 0272-4340 27:3<303 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer