caa a22 4500 463254457 CHVBK 20180405153350.0 cr unu---uuuuu 170326e20070501xx s 000 0 eng 10.1007/s10571-006-9128-7 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9128-7 Hippocampal CA1 Pyramidal Cell Size is Reduced in Bipolar Disorder [Elektronische Daten] [Lusha Liu, S. Schulz, Susanne Lee, Teri Reutiman, S. Fatemi] 1. Schizophrenia and bipolar disorder are neurodevelopmental disorders with significant genetic vulnerabilities. Several trophic genes and/or proteins have been implicated in the causation for both disorders. 2. We hypothesized that these genes and/or proteins may impact neuronal growth in both disorders. 3. Hippocampal tissue sections from CA1 area of schizophrenic, bipolar, depressed, and controls subjects, matched for age, sex, PMI, drug exposure, and brain pH were prepared for cell size determination using the Stanley Medical Research Foundation postmortem brain collection. 4. Quantification of hippocampal CA1 pyramidal neuron size showed a significant 12% reduction in cell size (p < 0.05) in bipolar subjects vs. controls. There were nonsignificant trends for reduction in cell size in both schizophrenic and depressed subjects vs. controls. 5. These results indicate for the first time that pyramidal cell atrophy is present in hippocampus of subjects with bipolar disorder. Springer Science+Business Media, LLC, 2006 schizophrenia nationallicence hippocampus nationallicence bipolar disorder nationallicence pyramidal cell size nationallicence Reelin nationallicence Bcl-2 nationallicence DISC1 nationallicence major depression nationallicence Liu Lusha Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut Schulz S. Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut Lee Susanne Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut Reutiman Teri Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut Fatemi S. Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/3(2007-05-01), 351-358 0272-4340 27:3<351 2007 27 10571 https://doi.org/10.1007/s10571-006-9128-7 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9128-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Lusha Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 700 1- Schulz S. Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 700 1- Lee Susanne Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 700 1- Reutiman Teri Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 700 1- Fatemi S. Department of Psychiatry, University of Minnesota, Minneapolis, Minnesota, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/3(2007-05-01), 351-358 0272-4340 27:3<351 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer