caa a22 4500 463254538 CHVBK 20180405153350.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s10571-006-9133-x doi (NATIONALLICENCE)springer-10.1007/s10571-006-9133-x Vitanova Lily Department of Physiology, Medical University, 1 G. Sofiisky Street, 1431, Sofia, Bulgaria aut AMPA and Kainate Receptors in Turtle Retina: An Immunocytochemical Study [Elektronische Daten] [Lily Vitanova] Summary: 1. Glutamate is one of the main neurotransmitters in the retina. Its effects are mediated by a large number of ionotropic and metabotropic receptors. 2. The distribution of ionotropic AMPA receptor subunits GluR1-4, kainate receptor subunits GluR5-7 and KA2, as well as delta receptors 1-2 was studied in turtle retina. Indirect immunofluorescence was used to localize the different receptor subunits viewed using light microscopy. 3. Results show that all subunits, with excerption of GluR1 and GluR5, are widely distributed in the turtle retina. 4. They are mainly located in the both plexiform layers of the retina where punctate staining, a sign for synaptic localization, is observed. 5. The vast majority of the subunits possess specific pattern of staining that allow to suppose that they are involved in different retinal circuits. 6. It can be assumed that the GluR2/3 and GluR6/7 subunits are expressed on the dendrites of a subpopulation of bipolar cells that are immunopositive for α-isoform of protein kinase C (PKCα). The GluR2/3 and GluR6/7 subunits are most probably used by the same PKCα immunopositive bipolar cells in their synaptic contacts with the third-order retinal neurons, the amacrine and ganglion cells. Springer Science+Business Media, LLC, 2007 turtle retina nationallicence immunocytochemistry nationallicence AMPA receptor subunits nationallicence kainate receptor subunits nationallicence delta receptors nationallicence Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/4(2007-06-01), 407-421 0272-4340 27:4<407 2007 27 10571 https://doi.org/10.1007/s10571-006-9133-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9133-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Vitanova Lily Department of Physiology, Medical University, 1 G. Sofiisky Street, 1431, Sofia, Bulgaria aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/4(2007-06-01), 407-421 0272-4340 27:4<407 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer