caa a22 4500 463254600 CHVBK 20180405153351.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10571-007-9189-2 doi (NATIONALLICENCE)springer-10.1007/s10571-007-9189-2 Membrane Organization and Function of the Serotonin1A Receptor [Elektronische Daten] [Shanti Kalipatnapu, Amitabha Chattopadhyay] (1) The serotonin1A receptor is a G-protein coupled receptor involved in several cognitive, behavioral, and developmental functions. It binds the neurotransmitter serotonin and signals across the membrane through its interactions with heterotrimeric G-proteins. (2) Lipid-protein interactions in membranes play an important role in the assembly, stability, and function of membrane proteins. The role of membrane environment in serotonin1A receptor function is beginning to be addressed by exploring the consequences of lipid manipulations on the ligand binding and G-protein coupling of serotonin1A receptors, the ability to functionally solubilize the serotonin1A receptor, and the factors influencing the membrane organization of the serotonin1A receptor. (3) Recent developments involving the application of detergent-based and detergent-free approaches to understand the membrane organization of the serotonin1A receptor under conditions of ligand activation and modulation of membrane lipid content, with an emphasis on membrane cholesterol, are described. Springer Science+Business Media, LLC, 2007 Serotonin1A receptor nationallicence G-protein coupling nationallicence Solubilization nationallicence Membrane lipid environment nationallicence Cholesterol nationallicence Detergent insolubility nationallicence Detergent-free approach nationallicence Kalipatnapu Shanti Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India aut Chattopadhyay Amitabha Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India aut Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/8(2007-12-01), 1097-1116 0272-4340 27:8<1097 2007 27 10571 https://doi.org/10.1007/s10571-007-9189-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-007-9189-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kalipatnapu Shanti Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India aut NATIONALLICENCE 700 1- Chattopadhyay Amitabha Centre for Cellular and Molecular Biology, Uppal Road, 500 007, Hyderabad, India aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/8(2007-12-01), 1097-1116 0272-4340 27:8<1097 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer