caa a22 4500 463254643 CHVBK 20180405153351.0 cr unu---uuuuu 170326e20071201xx s 000 0 eng 10.1007/s10571-007-9214-5 doi (NATIONALLICENCE)springer-10.1007/s10571-007-9214-5 Age and Sex Dependent Alteration in Presenilin Expression in Mouse Cerebral Cortex [Elektronische Daten] [Mahendra Thakur, Soumi Ghosh] (1) Presenilin (PS) expression is regulated by several cellular and extracellular factors which change with age and sex. Both age and sex are key risk factors for Alzheimer's disease (AD), which is linked to mutations in PS genes. (2) We have analyzed the effect of age and sex on PS expression by northern hybridization and western blot analysis using the cerebral cortex of adult (24±2weeks) and old (65±5weeks) mice. (3) Our results demonstrate that PS1 was downregulated and PS 2 was upregulated in old mice of both sexes. The level of PS 1 was relatively higher and that of PS 2 was lower in female than male mice of same age group. Taken together, these findings show age and sex dependent alteration in PS expression, which in turn may influence the signal transduction pathways and consequently brain functions. Springer Science+Business Media, LLC, 2007 Alzheimer's disease nationallicence Presenilin nationallicence Gene expression nationallicence Cerebral cortex nationallicence Mouse nationallicence Age nationallicence Sex nationallicence Northern hybridization nationallicence Western blotting nationallicence Thakur Mahendra Biochemistry & Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, 221005, Varanasi, Uttar Pradesh, India aut Ghosh Soumi Biochemistry & Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, 221005, Varanasi, Uttar Pradesh, India aut Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/8(2007-12-01), 1059-1067 0272-4340 27:8<1059 2007 27 10571 https://doi.org/10.1007/s10571-007-9214-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-007-9214-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thakur Mahendra Biochemistry & Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, 221005, Varanasi, Uttar Pradesh, India aut NATIONALLICENCE 700 1- Ghosh Soumi Biochemistry & Molecular Biology Laboratory, Department of Zoology, Banaras Hindu University, 221005, Varanasi, Uttar Pradesh, India aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Springer US; http://www.springer-ny.com 27/8(2007-12-01), 1059-1067 0272-4340 27:8<1059 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer