caa a22 4500 463254724 CHVBK 20180405153351.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s10571-006-9086-0 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9086-0 The Relevance of Neuroactive Steroids in Schizophrenia, Depression, and Anxiety Disorders [Elektronische Daten] [Erin MacKenzie, John Odontiadis, Jean-Michel Le Mellédo, Trevor Prior, Glen Baker] 1. Neuroactive steroids are steroid hormones that exert rapid, nongenomic effects at ligand-gated ion channels. There is increasing awareness of the possible role of these steroids in the pathology and manifestation of symptoms of psychiatric disorders. The aim of this paper is to review the current knowledge of neuroactive steroid functioning in the central nervous system, and to assess the role of neuroactive steroids in the pathophysiology and treatment of symptoms of schizophrenia, depression, and anxiety disorders. Particular emphasis will be placed on GABAA receptor modulation, given the extensive knowledge of the interactions between this receptor complex, neuroactive steroids, and psychiatric illness. 2. A brief description of neuroactive steroid metabolism is followed by a discussion of the interactions of neuroactive steroids with acute and chronic stress and the HPA axis. Preclinical and clinical studies related to psychiatric disorders that have been conducted on neuroactive steroids are also described. 3. Plasma concentrations of some neuroactive steroids are altered in individuals suffering from schizophrenia, depression, or anxiety disorders compared to values in healthy controls. Some drugs used to treat these disorders have been reported to alter plasma and brain concentrations in clinical and preclinical studies, respectively. 4. Further research is warranted into the role of neuroactive steroids in the pathophysiology of psychiatric illnesses and the possible role of these steroids in the successful treatment of these disorders. Springer Science+Business Media, Inc., 2006 neuroactive steroids nationallicence neurosteroids nationallicence γ-aminobutyric acid (GABA) nationallicence glutamic acid nationallicence psychiatry nationallicence stress nationallicence schizophrenia nationallicence depression nationallicence anxiety disorders nationallicence MacKenzie Erin Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut Odontiadis John Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut Le Mellédo Jean-Michel Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut Prior Trevor Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut Baker Glen Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/5(2007-07-01), 541-574 0272-4340 27:5<541 2007 27 10571 https://doi.org/10.1007/s10571-006-9086-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9086-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- MacKenzie Erin Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Odontiadis John Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Le Mellédo Jean-Michel Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Prior Trevor Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Baker Glen Bebensee Schizophrenia Research Unit and Neurochemical Research Unit, Department of Psychiatry, University of Alberta, 1E7.31 Walter MacKenzie Centre, T6G 2R7, Edmonton, Alberta, Canada aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/5(2007-07-01), 541-574 0272-4340 27:5<541 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer