caa a22 4500 463254856 CHVBK 20180405153351.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10571-006-9137-6 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9137-6 Interleukin-10 Regulated Gene Expression in Cells of Hypothalamic-Pituitary-Adrenal Axis Origin [Elektronische Daten] [Huolin Tu, Peter Rady, Terry Juelich, Stephen Tyring, Nina Koldzic-Zivanovic, Eric Smith, Thomas Hughes] 1. Aim: The hypothalamic-pituitary-adrenal (HPA) axis is a mediator for interactions between the immune and neuroendocrine systems. Pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) have been shown to activate the HPA axis. Recently, interleukin-10, an important anti-inflammatory cytokine in the immune system, has been shown to be expressed in the central nervous system and neuroendocrine system. Little is known, however, about IL-10's functions in the HPA axis. 2. Methods: The Affymetrix DNA microarray (mouse genome U74Av2 Probe Array) was conducted to determine the gene expression profile regulated by IL-10 in cells of HPA axis origin. 3. Results: In this study, we analyzed gene expression regulated by IL-10 in cells derived from the HPA axis. The results showed that quorums of genes are modulated by IL-10 in these neuroendocrine cells. 4. Conclusions: These findings will provide a valuable repository to aid in understanding IL-10's functions in the HPA axis at the molecular level. Springer Science+Business Media, LLC, 2007 interleukin-10 nationallicence hypothalamic-pituitary-adrenal axis nationallicence microarray nationallicence gene expression nationallicence Tu Huolin Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut Rady Peter Department of Dermatology, University of Texas Health Science Center, 77030, Houston, TX, USA aut Juelich Terry Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut Tyring Stephen Department of Dermatology, University of Texas Health Science Center, 77030, Houston, TX, USA aut Koldzic-Zivanovic Nina Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut Smith Eric Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut Hughes Thomas Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/2(2007-02-01), 161-170 0272-4340 27:2<161 2007 27 10571 https://doi.org/10.1007/s10571-006-9137-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9137-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tu Huolin Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut NATIONALLICENCE 700 1- Rady Peter Department of Dermatology, University of Texas Health Science Center, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Juelich Terry Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut NATIONALLICENCE 700 1- Tyring Stephen Department of Dermatology, University of Texas Health Science Center, 77030, Houston, TX, USA aut NATIONALLICENCE 700 1- Koldzic-Zivanovic Nina Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut NATIONALLICENCE 700 1- Smith Eric Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut NATIONALLICENCE 700 1- Hughes Thomas Department of Microbiology and Immunology, University of Texas Medical Branch, 301 University Blvd., 77555-1019, Galveston, TX, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/2(2007-02-01), 161-170 0272-4340 27:2<161 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer