caa a22 4500 463254864 CHVBK 20180405153351.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10571-006-9082-4 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9082-4 Neuroprotective Agents: Is Effective on Toxicity in Glial Cells? [Elektronische Daten] [Taner Dagci, Ozlem Yilmaz, Dilek Taskiran, Gonul Peker] 1. Glial cells are the most abundant cell population in the central nervous system. The aim of this study was to examine the effects of melatonin, 7-nitroindazole, and riluzole on glutamate toxicity in primary glial cell culture. 2. Glutamate toxicity was induced by addition of 100μM glutamate to the cultures, and then 100μM melatonin, 500μM 7-nitroindazole, and 10(M riluzole were administered in different groups. Lactate Dehydrogenase activity and nitrite levels were determined at the 1st, 6th, and 24thh. 3. Melatonin, 7-nitroindazole, and riluzole decrease Lactate Dehydrogenase activity at the 1st, 6th, and 24thh (at all hours, p<0.05). Nitrite levels were decreased by melatonin and riluzole at the 1st, 6th, and 24thh. 4. In this study, we observed that melatonin, 7-nitroindazole, and riluzole are effective as protective agents on glutamate toxicity in mixed glial cells. Springer Science + Business Media, Inc., 2006 primary cell culture nationallicence glutamate nationallicence melatonin nationallicence riluzole nationallicence 7-nitroindazole nationallicence Dagci Taner Ege University School of Medicine, Izmir, Turkey aut Yilmaz Ozlem Ege University School of Medicine, Izmir, Turkey aut Taskiran Dilek Ege University School of Medicine, Izmir, Turkey aut Peker Gonul Ege University School of Medicine, Izmir, Turkey aut Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/2(2007-02-01), 171-177 0272-4340 27:2<171 2007 27 10571 https://doi.org/10.1007/s10571-006-9082-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9082-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dagci Taner Ege University School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Yilmaz Ozlem Ege University School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Taskiran Dilek Ege University School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Peker Gonul Ege University School of Medicine, Izmir, Turkey aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/2(2007-02-01), 171-177 0272-4340 27:2<171 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer