caa a22 4500 463254880 CHVBK 20180405153352.0 cr unu---uuuuu 170326e20070201xx s 000 0 eng 10.1007/s10571-006-9094-0 doi (NATIONALLICENCE)springer-10.1007/s10571-006-9094-0 Hyperthermia-Induced Seizures Modify the GABAA and Benzodiazepine Receptor Binding in Immature Rat Brain [Elektronische Daten] [M. González Ramírez, S. Orozco Suárez, H. Salgado Ceballos, A. Feria Velasco, L. Rocha] Effects of hyperthermia-induced seizures (HS) on GABAA and benzodiazepine (BDZ) receptor binding in immature rat brain were evaluated using in vitro autoradiography. HS were induced in 10-days-old rats by a regulated stream of moderately heated air directed 50 cm above the animals. Rats were killed 30min, 24h or 20 days after HS and their brains were used for in vitro autoradiography experiments to determine GABAA and BDZ receptor binding. GABAA binding was significantly enhanced in all brain areas evaluated 30min after HS, an effect that endures 24h and 20 days after seizures. Concerning BDZ receptor binding, a significant increase was detected in entorhinal and perirhinal cortices and decreased in basolateral amygdala 30min following HS. One day after HS, animals demonstrated enhanced BDZ binding in the cingulate, frontal, posterior parietal, entorhinal, temporal and perirhinal cortices; striatum, accumbens, substantia nigra pars compacta and amygdala nuclei. Twenty days after HS enhanced BDZ binding was restricted in the cingulated, frontal, anterior and posterior parietal cortices, as well as in substantia nigra pars reticulata, whereas decreased values were found in accumbens nucleus and substantia nigra pars compacta. Our data indicate differential effects of HS in GABAA and BDZ binding in immature brain. HS-induced GABAA and BDZ changes are different from those previously described in experimental models of temporal lobe epilepsy in adult animals. Springer Science+Business Media, Inc., 2006 GABAA receptors nationallicence benzodiazepine receptors nationallicence immature brain nationallicence febrile seizures nationallicence hyperthermia-induced seizures nationallicence González Ramírez M. Unidad de Investigación Médica en Enfermedades Neurológicas, H. Especialidades, CMN S XXI, Av. Cuauhtémoc 330, C.P. 06720, Col. Doctores México D.F., México aut Orozco Suárez S. Unidad de Investigación Médica en Enfermedades Neurológicas, H. Especialidades, CMN S XXI, Av. Cuauhtémoc 330, C.P. 06720, Col. Doctores México D.F., México aut Salgado Ceballos H. Unidad de Investigación Médica en Enfermedades Neurológicas, H. Especialidades, CMN S XXI, Av. Cuauhtémoc 330, C.P. 06720, Col. Doctores México D.F., México aut Feria Velasco A. Unidad de Morfología de Alta Resolución CUCBA, Universidad de Guadalajara, Las Agujas Nextipac, Zapopan, C.P. 45100, Jal. México, México aut Rocha L. Depto. de Farmacobiología, Centro de Investigación y de Estudios Avanzados, Calz. Tenorios 235, C.P. 14330, México D.F., México, USA aut Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/2(2007-02-01), 211-227 0272-4340 27:2<211 2007 27 10571 https://doi.org/10.1007/s10571-006-9094-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10571-006-9094-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- González Ramírez M. Unidad de Investigación Médica en Enfermedades Neurológicas, H. Especialidades, CMN S XXI, Av. Cuauhtémoc 330, C.P. 06720, Col. Doctores México D.F., México aut NATIONALLICENCE 700 1- Orozco Suárez S. Unidad de Investigación Médica en Enfermedades Neurológicas, H. Especialidades, CMN S XXI, Av. Cuauhtémoc 330, C.P. 06720, Col. Doctores México D.F., México aut NATIONALLICENCE 700 1- Salgado Ceballos H. Unidad de Investigación Médica en Enfermedades Neurológicas, H. Especialidades, CMN S XXI, Av. Cuauhtémoc 330, C.P. 06720, Col. Doctores México D.F., México aut NATIONALLICENCE 700 1- Feria Velasco A. Unidad de Morfología de Alta Resolución CUCBA, Universidad de Guadalajara, Las Agujas Nextipac, Zapopan, C.P. 45100, Jal. México, México aut NATIONALLICENCE 700 1- Rocha L. Depto. de Farmacobiología, Centro de Investigación y de Estudios Avanzados, Calz. Tenorios 235, C.P. 14330, México D.F., México, USA aut NATIONALLICENCE 773 0- Cellular and Molecular Neurobiology Kluwer Academic Publishers-Plenum Publishers; http://www.springer-ny.com 27/2(2007-02-01), 211-227 0272-4340 27:2<211 2007 27 10571 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 463254880 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer