caa a22 4500 463255313 CHVBK 20180405153353.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00277-006-0194-1 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0194-1 Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss [Elektronische Daten] [Y. Nadir, R. Hoffman, B. Brenner] Hyperhomocysteinemia (HHC) is a known risk factor for venous and arterial thrombosis. Thrombophilia workup includes the level of homocysteine and other related parameters such as: vitamin B12, folic acid, and methylenetetrahydrofolate reductase (MTHFR) C677T genotype. As the levels of homocysteine, vitamin B12, folic acid, and MTHFR C677T genotype are linked biochemically, we hypothesized that a statistical association will be found between them. The purpose of the present study was to assess the association between the four parameters in patients with a thrombotic event or recurrent fetal loss. The potential study population included 326 patients who were referred to the Thrombosis and Hemostasis Unit; 125 of these patients had at least one pathological test result of the four parameters. The correlations between homocysteine and vitamin B12 as well as between homocysteine and folic acid were found to be weak (r = −0.236 and r = −0.209, respectively). No significant difference was revealed between the mean homocysteine level and the CC, CT, and TT MTHFR genotypes (p = 0.246). In conclusion, in the population studied, the association between homocysteine, vitamin B12, folic acid, and MTHFR C677T is weak. The results raise doubt as to whether the current routine evaluation of HHC, as part of thrombophilia workup, truly reflects the increased risk of thrombosis. Springer-Verlag, 2006 Homocysteine nationallicence Vitamin B12 nationallicence Folic acid nationallicence MTHFR C677T nationallicence Thrombosis and hemostasis nationallicence Nadir Y. Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, 31096, Haifa, Israel aut Hoffman R. Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, 31096, Haifa, Israel aut Brenner B. Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, 31096, Haifa, Israel aut Annals of Hematology Springer-Verlag 86/1(2007-01-01), 35-40 0939-5555 86:1<35 2007 86 277 https://doi.org/10.1007/s00277-006-0194-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0194-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nadir Y. Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, 31096, Haifa, Israel aut NATIONALLICENCE 700 1- Hoffman R. Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, 31096, Haifa, Israel aut NATIONALLICENCE 700 1- Brenner B. Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, 31096, Haifa, Israel aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/1(2007-01-01), 35-40 0939-5555 86:1<35 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer