caa a22 4500 463255399 CHVBK 20180405153353.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00277-006-0184-3 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0184-3 Polymorphisms of the methylenetetrahydrofolate reductase gene and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation [Elektronische Daten] [Inho Kim, Kyung-Hun Lee, Jin Kim, Eun Ra, Sung-Soo Yoon, Yun-Chul Hong, Sung Park, Chul Kim, Seonyang Park, Byoung Kim] To evaluate whether the C677T and A1298C polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) are related to the toxicity of methotrexate (MTX) used in allogeneic stem cell transplantation, we performed association analysis between these genetic polymorphisms and the clinical outcomes of patients treated using human leukocyte antigen-matched sibling stem cell transplantation. Patients (n=72) with hematological malignancy or aplastic anemia were given a short course of MTX as a graft-versus-host disease prophylaxis. Patients with the 677TT genotype showed higher total bilirubin levels (677TT vs 677CT vs 677CC, 14.5 vs 8.6 vs 3.8mg/dl, respectively; p=0.07) and higher aspartic transaminase levels (677TT vs 677CT vs 677CC, 678.9 vs 156.6 vs 111.8IU/l; p=0.04). Platelet recovery to 20,000/μl was slower for patients with the 677TT genotype than for patients with other genotypes (677TT, 59days; 677CT, 26days; 677CC, 26days; p=0.0075). The influences of the C677T polymorphism on treatment-related mortality (TRM) were also analyzed. One-year cumulative TRMs for patients with the TT genotype and the other genotypes were 66 and 30% (p=0.04) and their respective 1-year overall survivals were 30 and 56% (p=0.11). No association was observed between the A1298C polymorphism and clinical outcome for any of the different genotypes. Therefore, patients at high risk of developing hepatic toxicity and with a poor likelihood of survival could be selected by genotyping MTHFR C677T before allogeneic stem cell transplantation. Springer-Verlag, 2006 Methylenetetrahydrofolate reductase nationallicence Polymorphism nationallicence Stem cell transplantation nationallicence Methotrexate nationallicence Kim Inho Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut Lee Kyung-Hun Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut Kim Jin Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea aut Ra Eun Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea aut Yoon Sung-Soo Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut Hong Yun-Chul Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea aut Park Sung Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea aut Kim Chul Department of Internal Medicine, College of Medicine, Inha University, Incheon, Korea aut Park Seonyang Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut Kim Byoung Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut Annals of Hematology Springer-Verlag 86/1(2007-01-01), 41-48 0939-5555 86:1<41 2007 86 277 https://doi.org/10.1007/s00277-006-0184-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0184-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Inho Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Kyung-Hun Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Jin Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Ra Eun Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Yoon Sung-Soo Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Hong Yun-Chul Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Park Sung Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Chul Department of Internal Medicine, College of Medicine, Inha University, Incheon, Korea aut NATIONALLICENCE 700 1- Park Seonyang Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Byoung Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, 110-744, Seoul, South Korea aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/1(2007-01-01), 41-48 0939-5555 86:1<41 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer