caa a22 4500 463255402 CHVBK 20180405153353.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00277-006-0167-4 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0167-4 Unsuspected FDG-PET findings in the follow-up of patients with lymphoma [Elektronische Daten] [Anne Sonet, Carlos Graux, Marie-Cécile Nollevaux, Bruno Krug, André Bosly, Thierry Vander Borght] 18F-Fluorodeoxyglucose-positron emission tomography (FDG-PET) plays an increasing role in the management of patients with lymphoma, for which it is successfully used for staging and treatment monitoring. We report seven patients with a history of lymphoma who presented a positive FDG-PET suggestive of lymphoma relapse and for which FDG-PET oriented biopsies revealed alternative diagnoses. Early in lymphoma follow-up, persistence of focal increased FDG activity corresponded to inflammatory or infectious lesions in two patients: one aspergillosis and one sarcoidosis. Later in the follow-up, five cases of secondary malignancies were identified (three lung cancers, one epidermoid carcinoma, and one villous tumor) in this particularly exposed population. The routine use of FDG PET to evaluate lymphoma significantly increases the probability of detecting unexpected diseases. These cases illustrate the potential pitfalls in PET follow-up. Because FDG is not lymphoma-specific, a relapse suspected only on FDG-PET imaging requires biopsy, as alternative diagnoses—infectious or malignant—are possible. Our data draws clinician's attention to potential false-positive FDG-PET findings, which may lead to therapeutic mistakes. Our data also suggests that FDG-PET might be a new imaging modality for long-term monitoring of late effects, especially second cancer occurrence. Springer-Verlag, 2006 18F-Fluorodeoxyglucose (FDG) nationallicence Positron emission tomography (PET) nationallicence Lymphoma nationallicence Pitfalls nationallicence Second cancers nationallicence Sonet Anne Department of Hematology, Mont-Godinne Medical Center, Université Catholique de Louvain, 1 Dr. G. Therasse, 5530, Yvoir, Belgium aut Graux Carlos Department of Hematology, Mont-Godinne Medical Center, Université Catholique de Louvain, 1 Dr. G. Therasse, 5530, Yvoir, Belgium aut Nollevaux Marie-Cécile Department Pathology, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium aut Krug Bruno Department Nuclear Medicine, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium aut Bosly André Department of Hematology, Mont-Godinne Medical Center, Université Catholique de Louvain, 1 Dr. G. Therasse, 5530, Yvoir, Belgium aut Vander Borght Thierry Department Nuclear Medicine, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium aut Annals of Hematology Springer-Verlag 86/1(2007-01-01), 9-15 0939-5555 86:1<9 2007 86 277 https://doi.org/10.1007/s00277-006-0167-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0167-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sonet Anne Department of Hematology, Mont-Godinne Medical Center, Université Catholique de Louvain, 1 Dr. G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Graux Carlos Department of Hematology, Mont-Godinne Medical Center, Université Catholique de Louvain, 1 Dr. G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Nollevaux Marie-Cécile Department Pathology, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium aut NATIONALLICENCE 700 1- Krug Bruno Department Nuclear Medicine, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium aut NATIONALLICENCE 700 1- Bosly André Department of Hematology, Mont-Godinne Medical Center, Université Catholique de Louvain, 1 Dr. G. Therasse, 5530, Yvoir, Belgium aut NATIONALLICENCE 700 1- Vander Borght Thierry Department Nuclear Medicine, Mont-Godinne Medical Center, Université Catholique de Louvain, Yvoir, Belgium aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/1(2007-01-01), 9-15 0939-5555 86:1<9 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer