caa a22 4500 463255410 CHVBK 20180405153353.0 cr unu---uuuuu 170326e20070101xx s 000 0 eng 10.1007/s00277-006-0180-7 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0180-7 Effect of zoledronic acid on markers of bone turnover and mineral density in osteoporotic patients with beta-thalassaemia [Elektronische Daten] [Vassilios Perifanis, Timoleon Vyzantiadis, Konstantinos Tziomalos, Sofia Vakalopoulou, Vassilia Garipidou, Miranda Athanassiou-Metaxa, Faidon Harsoulis] Osteoporosis has emerged as an important cause of morbidity in patients with thalassemia major. Studies regarding the efficacy of bisphosphonates in thalassemia-induced osteoporosis have yielded conflicting results. We performed this prospective study to evaluate the efficacy of zoledronic acid in osteoporotic patients with thalassemia major. Patients, 29, were given 1mg zoledronic acid intravenously every 3months for a total of four doses. Twenty age- and sex-matched healthy blood donors served as controls. Before each infusion and 3months after the last infusion, we determined serum levels of osteoprotegerin (OPG), N-terminal cross-linking telopeptide of type I collagen (NTX), osteocalcin (OC) and insulin-like growth factor 1 (IGF-1). Bone mineral density (BMD) of the lumbar spine was measured at baseline and after the treatment's completion. At baseline, OPG did not differ significantly between patients and controls (p=0.2), NTX were higher in patients although not significantly (p=0.139), whereas, OC levels were significantly higher and IGF-1 levels significantly lower in patients than in controls (p<0.001 and p<0.006, respectively). Zoledronic acid administration resulted in a significant decrease in NTX, OC and IGF-1 (p<0.05, p<0.001 and p<0.05, respectively) and in a significant increase in OPG and BMD (p<0.05 for both comparisons). The change in NTX, osteocalcin and IGF-1 became significant as early as 3months after the first administration of zoledronic acid, while the change in OPG reached significance only after three infusions. Our study supports the effectiveness of bisphosphonates in the treatment of thalassemia-induced osteoporosis. Springer-Verlag, 2006 Zoledronic acid nationallicence Osteoporosis nationallicence Beta-thalassaemia major nationallicence Osteoprotegerin nationallicence Insulin-like growth factor 1 nationallicence Bisphosphonates nationallicence Osteocalcin nationallicence Perifanis Vassilios Thalassaemia Unit, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut Vyzantiadis Timoleon 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut Tziomalos Konstantinos 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut Vakalopoulou Sofia 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut Garipidou Vassilia 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut Athanassiou-Metaxa Miranda Thalassaemia Unit, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut Harsoulis Faidon 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut Annals of Hematology Springer-Verlag 86/1(2007-01-01), 23-30 0939-5555 86:1<23 2007 86 277 https://doi.org/10.1007/s00277-006-0180-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0180-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Perifanis Vassilios Thalassaemia Unit, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Vyzantiadis Timoleon 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Tziomalos Konstantinos 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Vakalopoulou Sofia 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Garipidou Vassilia 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Athanassiou-Metaxa Miranda Thalassaemia Unit, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 700 1- Harsoulis Faidon 2nd Propedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, Hippokration General Hospital, Thessaloniki, Greece aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/1(2007-01-01), 23-30 0939-5555 86:1<23 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer