caa a22 4500 46325547X CHVBK 20180405153353.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s00277-007-0257-y doi (NATIONALLICENCE)springer-10.1007/s00277-007-0257-y Predictive echo-Doppler indices of left ventricular impairment in B-thalassemic patients [Elektronische Daten] [Athanassios Aessopos, Spyros Deftereos, Maria Tsironi, Fotios Karabatsos, Jacqueline Yousef, Christina Fragodimitri, Antonia Hatziliami, Markissia Karagiorga] Early detection of cardiac-function impairment by echo-Doppler indices can assist in preventing further cardiac damage by modifying disease progression and treatment. We analyzed our thalassemia major patients database with 10years cardiac follow-up. Included patients were under constant therapy and should have an initial echo-Doppler study with normal Shortening Fraction (SF > 30%) and reexamination within the last year. We identified patients who developed impaired left ventricular (LV) function in the last Echo and we attempted to find which measured indices could predict LV function impairment. Three hundred fifteen of the 632 database patients were enrolled. Twelve of them developed LV systolic dysfunction. There were no statistically significant differences in mean age, ferritin, and pretransfusion hemoglobin levels of the two groups. LV-systolic-dysfunction group was presenting statistically significantly higher LF end-systolic diameter (LVESD) index, lower SF, higher early transmitral peak flow velocities/late transmitral peak flow velocities (A) ratios, lower A value. All other echocardiographic parameters did not differ significantly. By receiver-operating characteristic analysis, we determined systolic and diastolic indices specificity and sensitivity for LV impairment: LVESD 97% specificity, 11% sensitivity (cutoff value 2.44cm/m2 ), SF 92.1 and 33.3% (cutoff value 33%). Regarding diastolic indices, A index was the best criterion (97.7% specificity, 25% sensitivity, cutoff value ≤0.36). Low values of the diastolic index A wave and increased values of the LVESD index were the earliest pathological findings in patients that finally developed LV systolic dysfunction. These parameters could be used as heart-dysfunction predictors with relatively good sensitivity and specificity. Springer-Verlag, 2007 Heart dysfunction nationallicence β-thalassemia nationallicence Chelation nationallicence Echocardiography nationallicence Aessopos Athanassios First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Deftereos Spyros First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Tsironi Maria First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Karabatsos Fotios First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Yousef Jacqueline First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Fragodimitri Christina First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Hatziliami Antonia First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Karagiorga Markissia First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut Annals of Hematology Springer-Verlag 86/6(2007-06-01), 429-434 0939-5555 86:6<429 2007 86 277 https://doi.org/10.1007/s00277-007-0257-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-007-0257-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aessopos Athanassios First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Deftereos Spyros First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Tsironi Maria First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Karabatsos Fotios First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Yousef Jacqueline First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Fragodimitri Christina First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Hatziliami Antonia First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 700 1- Karagiorga Markissia First Dept. of Internal Medicine, University of Athens Medical School, "Laiko” Hospital, Ag. Thoma 17, 11527, Athens, Greece aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/6(2007-06-01), 429-434 0939-5555 86:6<429 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer