caa a22 4500 463255577 CHVBK 20180405153354.0 cr unu---uuuuu 170326e20070601xx s 000 0 eng 10.1007/s00277-007-0263-0 doi (NATIONALLICENCE)springer-10.1007/s00277-007-0263-0 Sestamibi and FDG-PET scans to support diagnosis of jaw osteonecrosis [Elektronische Daten] [Lucio Catalano, Silvana Del Vecchio, Fara Petruzziello, Rosa Fonti, Barbara Salvatore, Carmen Martorelli, Catello Califano, Giuseppe Caparrotti, Sabrina Segreto, Leonardo Pace, Bruno Rotoli] Osteonecrosis of the maxillary or mandibular bone is an infrequent but often severe event occurring in patients who undergo prolonged treatment with bisphosphonates. Histology is in some cases mandatory to differentiate it from neoplastic osteolysis, but a biopsy can further contribute to bone damage. Functional imaging obtained by a tracer that shows oncotropic properties, such as Tc99m-sestamibi, in comparison to a non-tumor-specific substance such as FDG-PET, can support the differential diagnosis, thus avoiding invasive procedures. Four patients affected by multiple myeloma and jaw osteonecrosis were prospectively evaluated by sestamibi and FDG-PET scans. Local diagnosis was performed by clinical, radiological and, in some cases, histological evaluations. Each patient was studied by Tc99m-sestamibi, performed by planar anterior and posterior whole-body scans and SPECT of the head and neck, and by PET/CT. Two nuclear medicine physicians, unaware of the final diagnosis, reviewed the images. No sestamibi uptake was evident in the four patients with jaw osteonecrosis, while FDG-PET/CT showed focal uptake in all of them. Our study suggests that the combined use of sestamibi scintigraphy and FDG-PET/CT could support the clinical diagnosis of oral osteonecrosis avoiding the risks of a surgical biopsy. Studies on higher number of patients are necessary to validate these preliminary observations. Springer-Verlag, 2007 Multiple myeloma nationallicence Sestamibi nationallicence FDG-PET nationallicence Jaw osteonecrosis nationallicence Bisphophonates nationallicence Catalano Lucio Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut Del Vecchio Silvana Cattedra di Radiologia, Università Federico II, Napoli, Italy aut Petruzziello Fara Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut Fonti Rosa Cattedra di Radiologia, Università Federico II, Napoli, Italy aut Salvatore Barbara Cattedra di Radiologia, Università Federico II, Napoli, Italy aut Martorelli Carmen Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut Califano Catello Divisione di Emato-Oncologia, Ospedale "Umberto I”, ASL SA1, Nocera Inferiore (SA), Italy aut Caparrotti Giuseppe Divisione di Ematologia, Ospedale di S. Felice a Cancello, ASL Caserta 1, Italy aut Segreto Sabrina Cattedra di Radiologia, Università Federico II, Napoli, Italy aut Pace Leonardo Cattedra di Radiologia, Università Federico II, Napoli, Italy aut Rotoli Bruno Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut Annals of Hematology Springer-Verlag 86/6(2007-06-01), 415-423 0939-5555 86:6<415 2007 86 277 https://doi.org/10.1007/s00277-007-0263-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-007-0263-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Catalano Lucio Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Del Vecchio Silvana Cattedra di Radiologia, Università Federico II, Napoli, Italy aut NATIONALLICENCE 700 1- Petruzziello Fara Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Fonti Rosa Cattedra di Radiologia, Università Federico II, Napoli, Italy aut NATIONALLICENCE 700 1- Salvatore Barbara Cattedra di Radiologia, Università Federico II, Napoli, Italy aut NATIONALLICENCE 700 1- Martorelli Carmen Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 700 1- Califano Catello Divisione di Emato-Oncologia, Ospedale "Umberto I”, ASL SA1, Nocera Inferiore (SA), Italy aut NATIONALLICENCE 700 1- Caparrotti Giuseppe Divisione di Ematologia, Ospedale di S. Felice a Cancello, ASL Caserta 1, Italy aut NATIONALLICENCE 700 1- Segreto Sabrina Cattedra di Radiologia, Università Federico II, Napoli, Italy aut NATIONALLICENCE 700 1- Pace Leonardo Cattedra di Radiologia, Università Federico II, Napoli, Italy aut NATIONALLICENCE 700 1- Rotoli Bruno Cattedra di Ematologia, Federico II University, via Pansini 5, 80131, Napoli, Italy aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/6(2007-06-01), 415-423 0939-5555 86:6<415 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer