caa a22 4500 463255755 CHVBK 20180405153354.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00277-006-0249-3 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0249-3 Secondary myelodysplastic syndrome after hydroxychloroquine therapy [Elektronische Daten] [Alaa Muslimani, Timothy Spiro, Asif Chaudhry, Hamed Daw] Primary myelodysplastic syndromes (MDS) occur in the absence of exposure to ionizing radiation, chemotherapeutic agents or myelotoxic drugs, whereas secondary MDS occurs in the presence of such exposure. We encountered 4 patients among 217 patients on hydroxychloroquine for rheumatological conditions in 2005 diagnosed with MDS. Two patients were male and two were female; the median age was 69.75years, (range 65-76). The dose of hydroxychloroquine for all patients was 400mg daily with median treatment duration of 10.5years and a range of 6-16. All patients had bone marrow biopsy confirmation of the diagnosis of MDS. The incidence of MDS in a group older than 70years ranges from 15 to 50/100,000 persons per year. The diagnosis of 4 cases of MDS among 217 patients in 1year is approximately 123-137-fold higher than the risk of MDS in the general population aged more than 70years (P < 0.001) and suggests that long-term treatment with hydroxychloroquine is associated with an increased risk of developing secondary MDS. Springer-Verlag, 2007 Secondary myelodysplastic syndrome nationallicence Hydroxychloroquine nationallicence Muslimani Alaa Department of Internal Medicine, Cleveland Clinic Health System, Fairview Hospital, Moll Pavilion, Cleveland, OH, USA aut Spiro Timothy Cleveland Clinic Cancer Center, Moll Pavilion, 18200 Lorain Ave, 44111, Cleveland, OH, USA aut Chaudhry Asif Cleveland Clinic Cancer Center, Moll Pavilion, 18200 Lorain Ave, 44111, Cleveland, OH, USA aut Daw Hamed Cleveland Clinic Cancer Center, Moll Pavilion, 18200 Lorain Ave, 44111, Cleveland, OH, USA aut Annals of Hematology Springer-Verlag 86/7(2007-07-01), 531-534 0939-5555 86:7<531 2007 86 277 https://doi.org/10.1007/s00277-006-0249-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0249-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Muslimani Alaa Department of Internal Medicine, Cleveland Clinic Health System, Fairview Hospital, Moll Pavilion, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Spiro Timothy Cleveland Clinic Cancer Center, Moll Pavilion, 18200 Lorain Ave, 44111, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Chaudhry Asif Cleveland Clinic Cancer Center, Moll Pavilion, 18200 Lorain Ave, 44111, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Daw Hamed Cleveland Clinic Cancer Center, Moll Pavilion, 18200 Lorain Ave, 44111, Cleveland, OH, USA aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/7(2007-07-01), 531-534 0939-5555 86:7<531 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer