caa a22 4500 463255828 CHVBK 20180405153354.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00277-007-0278-6 doi (NATIONALLICENCE)springer-10.1007/s00277-007-0278-6 Lymphoma-associated hemophagocytic syndrome: clinical features and treatment outcome [Elektronische Daten] [A-Reum Han, Hye Lee, Byeong-Bae Park, In Hwang, Sarah Park, Sang Lee, Kihyun Kim, Ho Lim, Young Ko, Sun Kim, Won Kim] The clinical features and prognostic factor of lymphoma-associated hemophagocytic syndrome (LAHS), diagnosed according to World Health Organization classification, were investigated by reviewing the clinical records of 29 patients between September 1994 and September 2006. Compared with patients with T or natural killer (NK)/T cell LAHS, patients with B cell LAHS were older (p = 0.022), were less likely to exhibit disseminated intravascular coagulation (DIC; p = 0.011), and had less direct involvement of bone marrow (p = 0.03). Clinical response was achieved in 15 (65.2%) and complete remission (CR) was achieved in 4 (17%) of 23 patients who received chemotherapy. Four patients received high-dose chemotherapy and autologous stem cell transplantation (A-SCT), and three of these four patients showed CR. The median survival was 36days (95%CI, 20.2-51.8). Univariate analysis showed that poor performance status (p = 0.028), T or NK/T cell lymphoma (p = 0.016), presence of jaundice (p = 0.063), the presence of DIC (p = 0.002), and poor clinical response to treatment (p < 0.001) predicted poor overall survival. These data suggest that the clinical features differ significantly between B cell LAHS and T or NK/T cell LAHS. Intensive treatment including high-dose chemotherapy and A-SCT should be investigated. Springer-Verlag, 2007 Hemophagocytic syndrome nationallicence Lymphoma-associated hemophagocytic syndrome nationallicence Han A-Reum Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea aut Lee Hye Division of Hematology-Oncology, Department of Medicine, Paik Hospital, Inje University School of Medicine, Seoul, South Korea aut Park Byeong-Bae Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut Hwang In Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut Park Sarah Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut Lee Sang Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut Kim Kihyun Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut Lim Ho Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut Ko Young Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea aut Kim Sun Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea aut Kim Won Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut Annals of Hematology Springer-Verlag 86/7(2007-07-01), 493-498 0939-5555 86:7<493 2007 86 277 https://doi.org/10.1007/s00277-007-0278-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-007-0278-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Han A-Reum Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Hye Division of Hematology-Oncology, Department of Medicine, Paik Hospital, Inje University School of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Park Byeong-Bae Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut NATIONALLICENCE 700 1- Hwang In Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut NATIONALLICENCE 700 1- Park Sarah Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Sang Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Kihyun Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut NATIONALLICENCE 700 1- Lim Ho Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut NATIONALLICENCE 700 1- Ko Young Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Sun Department of Laboratory Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Won Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, 135-710, Seoul, South Korea aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/7(2007-07-01), 493-498 0939-5555 86:7<493 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer