caa a22 4500 463255844 CHVBK 20180405153355.0 cr unu---uuuuu 170326e20070701xx s 000 0 eng 10.1007/s00277-007-0289-3 doi (NATIONALLICENCE)springer-10.1007/s00277-007-0289-3 Highly aggressive ALK-positive anaplastic large cell lymphoma with a leukemic phase and multi-organ involvement: a report of three cases and a review of the literature [Elektronische Daten] [Jaspreet Grewal, Lauren Smith, Jerome Winegarden III, John Krauss, Joseph Tworek, Bertram Schnitzer] Anaplastic large cell lymphoma (ALCL) is an aggressive neoplasm of T- or null cell phenotype and is recognized as a distinct clinicopathologic subtype of non-Hodgkin lymphoma (NHL) in the revised World Health Organization (WHO) classification of hematopoietic neoplasms. It is rarely associated with leukemic phase. Most cases with leukemic involvement are the small cell variant of ALCL. These cases often lack the pleomorphism seen in the common variant of ALCL and may be misdiagnosed. We report a series of three patients who presented with leukemic phase ALCL. The patients included an 11-year-old boy, a 29-year-old man, and a 59-year-old woman. The clinical and pathologic features of these cases are reviewed. The patients in our case series with leukemic phase ALCL exhibited rare clinical features. The patients presented with massive extranodal disease involving cerebrospinal fluid (CSF), liver, spleen, lungs, and bone marrow. CSF involvement was documented morphologically as well as by flow cytometry in two patients. Two of the patients had small cell variant and the third patient had common type ALCL. The neoplastic cells in all three patients were ALK positive; however these patients died within months of diagnosis. Leukemic phase ALCL is rare, and behaves in an aggressive manner. Some, but not all, cases in the literature presenting with peripheral blood involvement had small cell variant ALCL, as seen in two of our cases. The leukemic phase of ALCL should be considered when a T-cell leukemia with unusual morphologic features is encountered. Springer-Verlag, 2007 Anaplastic large cell lymphoma nationallicence Small cell variant nationallicence Anaplastic lymphoma kinase nationallicence ALK nationallicence Grewal Jaspreet Department of Internal Medicine, Reichert Health Center, St. Joseph Mercy Hospital, 5333 McAuley Drive Suite 3009, 48106-0995, Ann Arbor, MI, USA aut Smith Lauren Department of Pathology, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA aut Winegarden III Jerome Ann Arbor Hematology/Oncology Associates, St. Joseph Mercy Hospital, 48106, Ann Arbor, MI, USA aut Krauss John Ann Arbor Hematology/Oncology Associates, St. Joseph Mercy Hospital, 48106, Ann Arbor, MI, USA aut Tworek Joseph Department of Pathology, St. Joseph Mercy Hospital, 48106, Ann Arbor, MI, USA aut Schnitzer Bertram Department of Pathology, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA aut Annals of Hematology Springer-Verlag 86/7(2007-07-01), 499-508 0939-5555 86:7<499 2007 86 277 https://doi.org/10.1007/s00277-007-0289-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-007-0289-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Grewal Jaspreet Department of Internal Medicine, Reichert Health Center, St. Joseph Mercy Hospital, 5333 McAuley Drive Suite 3009, 48106-0995, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Smith Lauren Department of Pathology, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Winegarden III Jerome Ann Arbor Hematology/Oncology Associates, St. Joseph Mercy Hospital, 48106, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Krauss John Ann Arbor Hematology/Oncology Associates, St. Joseph Mercy Hospital, 48106, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Tworek Joseph Department of Pathology, St. Joseph Mercy Hospital, 48106, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Schnitzer Bertram Department of Pathology, University of Michigan Medical Center, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/7(2007-07-01), 499-508 0939-5555 86:7<499 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer