caa a22 4500 463256050 CHVBK 20180405153355.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s00277-006-0239-5 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0239-5 Towards a new age in the treatment of multiple myeloma [Elektronische Daten] [Francesco Piazza, Carmela Gurrieri, Livio Trentin, Gianpietro Semenzato] Multiple myeloma (MM) is an incurable disease characterized by the proliferation of end-stage B lymphocytes (plasma cells, PCs). As a consequence of myeloma growth in the bone marrow, a number of signaling pathways are activated that trigger malignant PC proliferation, escape from apoptosis, migration, and invasion. Thanks to new insights into the molecular pathogenesis of MM, novel approaches aimed at targeting these abnormally activated cascades have recently been developed and others are under study. These strategies include the inhibition of membrane receptor tyrosine kinases, inhibition of the proteasome/aggresome machinery, inhibition of histone deacetylases, inhibition of farnesyltransferases, targeting of molecular chaperones, and others. We will herein review and discuss these novel biological approaches with particular emphasis on those based on biochemical pathways which drive cell signaling. By providing the rationale for innovative therapeutic strategies, the above mechanisms represent targets for new compounds being tested in the management of this disease. Springer-Verlag, 2007 Multiple myeloma nationallicence Microenvironment nationallicence Drug-resistance nationallicence Biological therapy nationallicence Cell signaling nationallicence Piazza Francesco Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Gurrieri Carmela Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Trentin Livio Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Semenzato Gianpietro Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut Annals of Hematology Springer-Verlag 86/3(2007-03-01), 159-172 0939-5555 86:3<159 2007 86 277 https://doi.org/10.1007/s00277-006-0239-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0239-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Piazza Francesco Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Gurrieri Carmela Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Trentin Livio Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 700 1- Semenzato Gianpietro Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani 2, 35128, Padova, Italy aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/3(2007-03-01), 159-172 0939-5555 86:3<159 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer