caa a22 4500 463256085 CHVBK 20180405153355.0 cr unu---uuuuu 170326e20070301xx s 000 0 eng 10.1007/s00277-006-0202-5 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0202-5 Lack of clinical efficacy of rituximab in the treatment of autoimmune neutropenia and pure red cell aplasia: implications for their pathophysiology [Elektronische Daten] [M. Dungarwalla, J. Marsh, J. Tooze, G. Lucas, W. Ouwehand, R. Pettengell, C. Dearden, E. Gordon Smith, M. Elebute] We describe 11 patients with severe refractory autoimmune cytopenias treated with the anti-CD20 monoclonal antibody rituximab. Six patients had autoimmune neutropenia (AIN), two had pure red cell aplasia (PRCA), one had AIN and autoimmune haemolytic anaemia, one had AIN and immune thrombocytopaenia purpura (ITP) and one had PRCA and ITP. Rituximab was administered at a dose of 375mg/m2 as an intravenous infusion weekly for 4weeks. Six of eight patients with AIN and all three patients with PRCA did not respond. Two patients died: one with resistant AIN and autoimmune haemolytic anaemia died of pneumocytis pneumonia infection, and one with PRCA and ITP died of an acute exacerbation of bronchiectasis. Rituximab in AIN and PRCA appears to be less effective than Campath-1H when compared to historical data from our group. This supports the hypothesis that T cells may be important in the pathophysiology of AIN and PRCA. Springer-Verlag, 2006 Rituximab nationallicence Campath-1H nationallicence Autoimmune neutropenia nationallicence Pure red cell aplasia nationallicence Dungarwalla M. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut Marsh J. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut Tooze J. Department of Cellular and Molecular Medicine, St George's University of London, London, UK aut Lucas G. International Blood Group Reference Laboratory, Bristol, UK aut Ouwehand W. Division of Transfusion Medicine, University of Cambridge and National Blood Service, East Anglia, Cambridge, UK aut Pettengell R. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut Dearden C. The Royal Marsden Hospital, London, UK aut Gordon Smith E. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut Elebute M. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut Annals of Hematology Springer-Verlag 86/3(2007-03-01), 191-197 0939-5555 86:3<191 2007 86 277 https://doi.org/10.1007/s00277-006-0202-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0202-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dungarwalla M. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut NATIONALLICENCE 700 1- Marsh J. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut NATIONALLICENCE 700 1- Tooze J. Department of Cellular and Molecular Medicine, St George's University of London, London, UK aut NATIONALLICENCE 700 1- Lucas G. International Blood Group Reference Laboratory, Bristol, UK aut NATIONALLICENCE 700 1- Ouwehand W. Division of Transfusion Medicine, University of Cambridge and National Blood Service, East Anglia, Cambridge, UK aut NATIONALLICENCE 700 1- Pettengell R. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut NATIONALLICENCE 700 1- Dearden C. The Royal Marsden Hospital, London, UK aut NATIONALLICENCE 700 1- Gordon Smith E. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut NATIONALLICENCE 700 1- Elebute M. Department of Haematology, St George's Hospital, Blackshaw Road, Tooting, SW17 0QT, London, UK aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/3(2007-03-01), 191-197 0939-5555 86:3<191 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer