caa a22 4500 463256328 CHVBK 20180405153356.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00277-006-0234-x doi (NATIONALLICENCE)springer-10.1007/s00277-006-0234-x Cytogenetics detects infiltrations of a primary cutaneous acute myeloid leukemia to the kidney [Elektronische Daten] [Maximilian Christopeit, Lutz Mueller, Michael Hainz, Hans-Jürgen Holzhausen, Gerhard Behre] Extramedullary manifestations of acute myeloid leukemia (AML) are rare and commonly involve one tissue. We report of a cutaneous acute myelomonocytic leukemia infiltrating the kidney next to the skin. A 61-year-old female patient with complex karyotype cutaneous AML FAB M4 underwent abdominal computed tomography scans. A lesion in her left kidney appeared suspicious of renal carcinoma as confirmed by histology. However, fluorescence in situ hybridization cytogenetics revealed a chromosome 11q23 abnormality in the nephrectomy specimen, which also appeared in the leukemic blasts of skin and bone marrow. Closer histomorphologic workup revealed an infiltration of the kidney with leukemia. This case report illustrates how modern diagnostic procedures can help to reveal rare sites of disease. Springer-Verlag, 2007 AML nationallicence Extramedullary nationallicence Skin nationallicence Kidney nationallicence Cytogenetics nationallicence Christopeit Maximilian Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV-Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany aut Mueller Lutz Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV-Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany aut Hainz Michael Institute for Pathology, Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse, 06097, Halle, Germany aut Holzhausen Hans-Jürgen Institute for Pathology, Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse, 06097, Halle, Germany aut Behre Gerhard Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV-Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany aut Annals of Hematology Springer-Verlag 86/4(2007-04-01), 291-293 0939-5555 86:4<291 2007 86 277 https://doi.org/10.1007/s00277-006-0234-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0234-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Christopeit Maximilian Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV-Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany aut NATIONALLICENCE 700 1- Mueller Lutz Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV-Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany aut NATIONALLICENCE 700 1- Hainz Michael Institute for Pathology, Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse, 06097, Halle, Germany aut NATIONALLICENCE 700 1- Holzhausen Hans-Jürgen Institute for Pathology, Martin-Luther-University Halle-Wittenberg, Magdeburger Strasse, 06097, Halle, Germany aut NATIONALLICENCE 700 1- Behre Gerhard Bone Marrow Transplantation Section, State Center for Cell and Gene Therapy, Department of Internal Medicine IV-Oncology and Hematology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097, Halle, Germany aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/4(2007-04-01), 291-293 0939-5555 86:4<291 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer