caa a22 4500 463256360 CHVBK 20180405153356.0 cr unu---uuuuu 170326e20070401xx s 000 0 eng 10.1007/s00277-006-0235-9 doi (NATIONALLICENCE)springer-10.1007/s00277-006-0235-9 Autologous peripheral blood stem cell transplantation in multiple myeloma using oral versus I.V. melphalan [Elektronische Daten] [J. Vela-Ojeda, M. García-Ruiz-Esparza, Y. Padilla-González, D. Gómez-Almaguer, C. Gutiérrez-Aguirre, D. Gómez-Rangel, A. Morales-Toquero, G. Ruiz-Delgado, J. Delgado-Lamas, G. Ruiz-Argüelles] Autologous peripheral blood stem cell transplantation is the therapy of choice for the treatment of multiple myeloma (MM) patients younger than 70years old. Between August 1993 and November 2004, 54 patients with MM were autografted after conditioning with high-dose oral melphalan 140mg/m2 in combination with etoposide and carmustine (28 patients) or with high-dose melphalan 200mg/m2 I.V. (26 patients). The oral and IV melphalan groups were comparable. There were no significant differences in disease-free survival (DFS) and overall survival (OS) between the groups; however, in patients transplanted in remission, OS and DFS were better in the I.V. melphalan group. Four good-prognostic factors were identified: interval between diagnosis and transplant <18months, number of prior chemotherapy lines ≤2, remission status (complete or partial), and the use of I.V. melphalan. In conclusion, I.V. melphalan is the therapy of choice for conditioning patients with MM who are in remission. Springer-Verlag, 2007 Stem cell autotransplants nationallicence Multiple myeloma nationallicence Oral and I.V. melphalan nationallicence Vela-Ojeda J. UMAE Hospital de Especialidades Centro Médico La Raza, IMSS, Apartado Postal 14-878 CP, 07001, México, D.F., México aut García-Ruiz-Esparza M. UMAE Hospital de Especialidades Centro Médico La Raza, IMSS, Apartado Postal 14-878 CP, 07001, México, D.F., México aut Padilla-González Y. UMAE Hospital de Especialidades Centro Médico La Raza, IMSS, Apartado Postal 14-878 CP, 07001, México, D.F., México aut Gómez-Almaguer D. Hospital Universitario de Nuevo León, Monterrey Nuevo León, México aut Gutiérrez-Aguirre C. Hospital Universitario de Nuevo León, Monterrey Nuevo León, México aut Gómez-Rangel D. Centro de Hematología y Medicina Interna de Puebla, Puebla, Puebla, México aut Morales-Toquero A. Centro de Hematología y Medicina Interna de Puebla, Puebla, Puebla, México aut Ruiz-Delgado G. Hospital Universitario de Nuevo León, Monterrey Nuevo León, México aut Delgado-Lamas J. UMAE Hospital de Especialidades Centro Médico de Occidente, IMSS, Guadalajara Jalisco, México aut Ruiz-Argüelles G. Centro de Hematología y Medicina Interna de Puebla, Puebla, Puebla, México aut Annals of Hematology Springer-Verlag 86/4(2007-04-01), 277-282 0939-5555 86:4<277 2007 86 277 https://doi.org/10.1007/s00277-006-0235-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00277-006-0235-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vela-Ojeda J. UMAE Hospital de Especialidades Centro Médico La Raza, IMSS, Apartado Postal 14-878 CP, 07001, México, D.F., México aut NATIONALLICENCE 700 1- García-Ruiz-Esparza M. UMAE Hospital de Especialidades Centro Médico La Raza, IMSS, Apartado Postal 14-878 CP, 07001, México, D.F., México aut NATIONALLICENCE 700 1- Padilla-González Y. UMAE Hospital de Especialidades Centro Médico La Raza, IMSS, Apartado Postal 14-878 CP, 07001, México, D.F., México aut NATIONALLICENCE 700 1- Gómez-Almaguer D. Hospital Universitario de Nuevo León, Monterrey Nuevo León, México aut NATIONALLICENCE 700 1- Gutiérrez-Aguirre C. Hospital Universitario de Nuevo León, Monterrey Nuevo León, México aut NATIONALLICENCE 700 1- Gómez-Rangel D. Centro de Hematología y Medicina Interna de Puebla, Puebla, Puebla, México aut NATIONALLICENCE 700 1- Morales-Toquero A. Centro de Hematología y Medicina Interna de Puebla, Puebla, Puebla, México aut NATIONALLICENCE 700 1- Ruiz-Delgado G. Hospital Universitario de Nuevo León, Monterrey Nuevo León, México aut NATIONALLICENCE 700 1- Delgado-Lamas J. UMAE Hospital de Especialidades Centro Médico de Occidente, IMSS, Guadalajara Jalisco, México aut NATIONALLICENCE 700 1- Ruiz-Argüelles G. Centro de Hematología y Medicina Interna de Puebla, Puebla, Puebla, México aut NATIONALLICENCE 773 0- Annals of Hematology Springer-Verlag 86/4(2007-04-01), 277-282 0939-5555 86:4<277 2007 86 277 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer