caa a22 4500 465729436 CHVBK 20180323111737.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02040313 doi (NATIONALLICENCE)springer-10.1007/BF02040313 Multielement investigation of human bile by means of instrumental neutron activation analysis [Elektronische Daten] [C. Schnier, H.-P. Benn] In a study on gold containing antirheumatic agents, the portion of gold that was eliminated via liver was quantified. Seven patients whose gall bladders had just been removed surgically received 5 tablets RIDAURA® containing a total amount of 4.35 mg gold in the chemical compound Auranofin. In the following 7 days samples of hepatic bile were collected and analyzed by instrumental neutron activation analysis (INAA). After a 3-day irradiation with neutrons in the Research Reactor Geesthacht (FRG) and after a waiting time of 5-10 days, the limit of detection for gold was about 0.03 ng. The gold concentration in bile reached the maximum value (≈65 ng/ml) after about 16 hours and decreased with a biological half-life, first of 21 hours and later, in the end phase, of 6.5 days. Further elements were determined in the hepatic bile: Na, Ca, Fe, Co, Zn, Se, Br, Rb, Cs, Ba, Hg and sporadically K, Sc, Cr, Ni, Sb, La, Ce, Eu, Tb, Hf, Ta, Th. Some of these elements occurred in clusters. The blank values of the quartz ampoules and the precision, accuracy and limit of detection of these elements are given. The element concentrations found in bile are compared with those in plasma and classified after BRAUER. Akadémiai Kiadó, 1990 Schnier C. GKSS Forschungszentrum Geesthacht GmbH, Max-Planck-Strasse, D-2054, Geesthacht, (FRG) aut Benn H.-P Medizinische Klinik und Poliklinik der Universität Kiel, Metzstrasse 53-57, D-2300, Kiel, (FRG) aut Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 142/2(1990-10-01), 433-443 0236-5731 142:2<433 1990 142 10967 https://doi.org/10.1007/BF02040313 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02040313 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schnier C. GKSS Forschungszentrum Geesthacht GmbH, Max-Planck-Strasse, D-2054, Geesthacht, (FRG) aut NATIONALLICENCE 700 1- Benn H.-P Medizinische Klinik und Poliklinik der Universität Kiel, Metzstrasse 53-57, D-2300, Kiel, (FRG) aut NATIONALLICENCE 773 0- Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 142/2(1990-10-01), 433-443 0236-5731 142:2<433 1990 142 10967 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 133548333 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer