caa a22 4500 465733298 CHVBK 20180323111747.0 cr unu---uuuuu 170327e19900101xx s 000 0 eng 10.1007/BF02162193 doi (NATIONALLICENCE)springer-10.1007/BF02162193 Radiopharmaceutical preparation of 3-123I-α-methyltyrosine for nuclearmedical applications [Elektronische Daten] [E. Knust, K. Dutschka, H. Machulla] α-Methyltyrosine was iodinated in position 3 of the aromatic ring by means of an electrophilic iodination method using chloramine-T in a phosphate buffer solution. In a mixture containing α-methyltyrosine, chloramine-T and a small amount of NaI as a carrier the reaction was complete within 15 min at room temperature. After purification by radio high pressure liquid chromatography /HPLC/ radiochemical yields of 77.6±3.2% were obtained. Radiochromatograms also revealed a small amount of an impurity, probably chlorinated 3-123I-α-methyltyrosine. After dissolving in isotonic phosphate buffer and sterile filtration the solution was ready for nuclear-medical applications. Akadémiai Kiadó, 1990 Knust E. Radiologisches Zentrum, Universitätsklinikum Essen, Hufelandstr. 55, D-4300, Essen, FRG aut Dutschka K. Radiologisches Zentrum, Universitätsklinikum Essen, Hufelandstr. 55, D-4300, Essen, FRG aut Machulla H. Radiologisches Zentrum, Universitätsklinikum Essen, Hufelandstr. 55, D-4300, Essen, FRG aut Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 144/2(1990-01-01), 107-113 0236-5731 144:2<107 1990 144 10967 https://doi.org/10.1007/BF02162193 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02162193 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Knust E. Radiologisches Zentrum, Universitätsklinikum Essen, Hufelandstr. 55, D-4300, Essen, FRG aut NATIONALLICENCE 700 1- Dutschka K. Radiologisches Zentrum, Universitätsklinikum Essen, Hufelandstr. 55, D-4300, Essen, FRG aut NATIONALLICENCE 700 1- Machulla H. Radiologisches Zentrum, Universitätsklinikum Essen, Hufelandstr. 55, D-4300, Essen, FRG aut NATIONALLICENCE 773 0- Journal of Radioanalytical and Nuclear Chemistry Kluwer Academic Publishers 144/2(1990-01-01), 107-113 0236-5731 144:2<107 1990 144 10967 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer