caa a22 4500 465733883 CHVBK 20180323111749.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00419941 doi (NATIONALLICENCE)springer-10.1007/BF00419941 Blood levels of active metabolites of vitamin D3 in fracture repair in humans [Elektronische Daten] A preliminary report [C. Tauber, D. Noff, M. Noff, C. Malkin] Summary: Blood levels of the active metabolites of vitamin D3, 25-hydroxycholecalciferol [25(OH)D3], 1,25-dihydroxycholecalciferol [1,25(OH)2D3] and 24,25-dihydroxycholecalciferol [24,25(OH)2D3] were determined in seven patients. Two subjects suffered from delayed union of tibial fractures; one showed a delayed union after a proximal tibial osteotomy; one patient suffered from bilateral femoral neck fractures, of which one failed to unite and the other united late; two patients had multiple fractures that united normally; and one patient exhibited staged bilateral femoral neck fractures whose occurrence was separated by a short interval and which united without undue delay. The blood levels of 25(OH)D3 were within the normal range. A relative decrease in 24,25(OH)2D3 values was noted in all patients, whereas in three subjects the decrease was absolute, to non-detectable levels. A decrease in 1,25(OH)2D3 levels was noted in only two patients. We postulate that these changes reflect the consumption of these metabolites during healing at the fracture site. Springer-Verlag, 1990 Tauber C. Department of Orthopaedics, Kaplan Hospital, 76100, Rehovot, Israel aut Noff D. Department of Pathological Chemistry, Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine of the Tel Aviv University, Tel Aviv, Israel aut Noff M. Department of Orthopaedics, Kaplan Hospital, 76100, Rehovot, Israel aut Malkin C. Department of Orthopaedics, Kaplan Hospital, 76100, Rehovot, Israel aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/5(1990-08-01), 265-267 0936-8051 109:5<265 1990 109 402 https://doi.org/10.1007/BF00419941 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00419941 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tauber C. Department of Orthopaedics, Kaplan Hospital, 76100, Rehovot, Israel aut NATIONALLICENCE 700 1- Noff D. Department of Pathological Chemistry, Sheba Medical Center, Tel Hashomer and the Sackler School of Medicine of the Tel Aviv University, Tel Aviv, Israel aut NATIONALLICENCE 700 1- Noff M. Department of Orthopaedics, Kaplan Hospital, 76100, Rehovot, Israel aut NATIONALLICENCE 700 1- Malkin C. Department of Orthopaedics, Kaplan Hospital, 76100, Rehovot, Israel aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/5(1990-08-01), 265-267 0936-8051 109:5<265 1990 109 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer