caa a22 4500 465733964 CHVBK 20180323111749.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00439382 doi (NATIONALLICENCE)springer-10.1007/BF00439382 Antibiotic prophylaxis in lower-extremity amputations due to ischemia [Elektronische Daten] A prospective, randomized trial of Cephalothin versus Methicillin [S. Thomsen, B.W. Jakobsen, J. Wethelund, J. Dalsgaard, H. Gregersen, U. Lucht] Summary: The efficiency of prophylactic antibiotic therapy in amputation surgery was studied in a prospective, randomized trial of a first-generation cephalosporin (cephalothin) compared with a narrow-spectrum betalactam stable penicillin (methicillin). Eighty-eight patients received cephalothin 2 g x 4 on the day of operation, while 86 patients received methicillin 1 g x 4. The patients were followed up for 21 days. Infected wounds occurred in 14.8% of the patients in the cephalothin group, compared with 14% in the methicillin group. The frequency of deep infections was 10.2% versus 4.7% (P = 0.1611). The reamputation frequency was 18.2% in the cephalothin group compared with 12.8% in the methicillin group; the frequency of below-knee reamputation was 18.4% versus 7.7% (P = 0.1469). No clostridial infections were found. The study did not demonstrate any significant difference between cephalothin and methicillin in the prophylaxis for lower-extremity amputations, although the latter drug tended to be the best choice. Springer-Verlag, 1990 Thomsen S. Department of Orthopedic Surgery O, Aalborg Hospital, Aalborg, Denmark aut Jakobsen B.W. Department of Orthopedic Surgery E, Aarhus Municipal Hospital, Aarhus, Denmark aut Wethelund J. Department of Orthopedic Surgery E, Aarhus Municipal Hospital, Aarhus, Denmark aut Dalsgaard J. Department of Orthopedic Surgery O, Aalborg Hospital, Aalborg, Denmark aut Gregersen H. Department of Orthopedic Surgery O, Aalborg Hospital, Aalborg, Denmark aut Lucht U. Department of Orthopedic Surgery E, Aarhus Municipal Hospital, Aarhus, Denmark aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/2(1990-02-01), 72-74 0936-8051 109:2<72 1990 109 402 https://doi.org/10.1007/BF00439382 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00439382 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Thomsen S. Department of Orthopedic Surgery O, Aalborg Hospital, Aalborg, Denmark aut NATIONALLICENCE 700 1- Jakobsen B.W. Department of Orthopedic Surgery E, Aarhus Municipal Hospital, Aarhus, Denmark aut NATIONALLICENCE 700 1- Wethelund J. Department of Orthopedic Surgery E, Aarhus Municipal Hospital, Aarhus, Denmark aut NATIONALLICENCE 700 1- Dalsgaard J. Department of Orthopedic Surgery O, Aalborg Hospital, Aalborg, Denmark aut NATIONALLICENCE 700 1- Gregersen H. Department of Orthopedic Surgery O, Aalborg Hospital, Aalborg, Denmark aut NATIONALLICENCE 700 1- Lucht U. Department of Orthopedic Surgery E, Aarhus Municipal Hospital, Aarhus, Denmark aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/2(1990-02-01), 72-74 0936-8051 109:2<72 1990 109 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer