caa a22 4500 465733980 CHVBK 20180323111749.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00439387 doi (NATIONALLICENCE)springer-10.1007/BF00439387 Induction of monocyte chemotaxis in devascularized rabbit bone [Elektronische Daten] [M. Sarkar, B. Rahn, U. Pfister, H. Keller, S. Perren] Summary: Temporary impairment of blood supply has been suggested to cause bone remodeling. The degradation of cells and matrix and the attraction of resorbing cells were examined in this study. Bone specimens of rabbits were stored in vitro for 2-20 days. At the end of this aging process the probes were tested for their chemotactic activity toward autologous leukocytes in a diffusion chamber. Both supernatant from the aged bone specimens and ground bone particles exhibited significant chemotactic activity that was specifically attracting monocytes. It is suggested that soluble bone matrix proteins or degeneration products liberated during ischemic damage to cortical bone initiate the resorptive process. Springer-Verlag, 1990 Sarkar M. Abteilung für Unfallchirurgie, Städtisches Klinikum, Karlsruhe, Germany aut Rahn B. Labor für experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Switzerland aut Pfister U. Abteilung für Unfallchirurgie, Städtisches Klinikum, Karlsruhe, Germany aut Keller H. Institut für Pathologie, Universität Bern, Bern, Switzerland aut Perren S. Labor für experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Switzerland aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/2(1990-02-01), 97-101 0936-8051 109:2<97 1990 109 402 https://doi.org/10.1007/BF00439387 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00439387 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sarkar M. Abteilung für Unfallchirurgie, Städtisches Klinikum, Karlsruhe, Germany aut NATIONALLICENCE 700 1- Rahn B. Labor für experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Switzerland aut NATIONALLICENCE 700 1- Pfister U. Abteilung für Unfallchirurgie, Städtisches Klinikum, Karlsruhe, Germany aut NATIONALLICENCE 700 1- Keller H. Institut für Pathologie, Universität Bern, Bern, Switzerland aut NATIONALLICENCE 700 1- Perren S. Labor für experimentelle Chirurgie, Schweizerisches Forschungsinstitut, Davos, Switzerland aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/2(1990-02-01), 97-101 0936-8051 109:2<97 1990 109 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer