caa a22 4500 465734014 CHVBK 20180323111749.0 cr unu---uuuuu 170327e19900201xx s 000 0 eng 10.1007/BF00439388 doi (NATIONALLICENCE)springer-10.1007/BF00439388 Quantitative and functional restorations and alterations of peripheral lymphocytes in patients with autologous spleen implantation [Elektronische Daten] [L. Bergmann, W. Böttcher, R. Seufert, P. Mitrou] Summary: To reduce the risk of severe infections in splenectomized patients, new methods for splenic preservation or heterotopic autologous spleen implantation have been established. In the latter case, the immunological and functional benefits are still under discussion. In this study we compared immunological parameters in 16 splenectomized patients with and without heterotopic autologous spleen implantation with a nonsplenectomized control group. The total lymphocyte counts — T-cells, CD4+ —, as well as CD8+ — lymphocytes, CD16+ — and B-cells — were highly elevated in both groups, whereby the B-cells were relatively and absolutely higher in the implanted group than in the nonimplanted group. Splenectomized patients had a significantly reduced serum IgM level. The serum IgM of patients with splenic auto-transplantation was not significantly lower than that of the controls. In contrast to the impaired in vitro immunoglobulin synthesis in the splenectomized group, the autotransplanted patients showed a normal PWM-induced IgG and IgM synthesis and an increased IgA production compared with the controls. The latter results support the findings of elevated serum IgA levels in this group. The mitogenic-induced proliferation with PHA, ConA, PWM, and OKT3 was not clearly different within the tested groups. The results may indicate a benefit of autologous spleen implantation in regard to the humoral immune response. Springer-Verlag, 1990 Bergmann L. Division of Hematology/Oncology, Department of Internal Medicine, University Clinics, Theodor-Stern-Kai 7, D-6000, Frankfurt/M, FRG aut Böttcher W. Department of Surgery, J. W. Goethe University, D-6000, Frankfurt, Germany aut Seufert R. Department of Surgery, J. W. Goethe University, D-6000, Frankfurt, Germany aut Mitrou P. Division of Hematology/Oncology, Department of Internal Medicine, University Clinics, Theodor-Stern-Kai 7, D-6000, Frankfurt/M, FRG aut Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/2(1990-02-01), 102-105 0936-8051 109:2<102 1990 109 402 https://doi.org/10.1007/BF00439388 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00439388 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bergmann L. Division of Hematology/Oncology, Department of Internal Medicine, University Clinics, Theodor-Stern-Kai 7, D-6000, Frankfurt/M, FRG aut NATIONALLICENCE 700 1- Böttcher W. Department of Surgery, J. W. Goethe University, D-6000, Frankfurt, Germany aut NATIONALLICENCE 700 1- Seufert R. Department of Surgery, J. W. Goethe University, D-6000, Frankfurt, Germany aut NATIONALLICENCE 700 1- Mitrou P. Division of Hematology/Oncology, Department of Internal Medicine, University Clinics, Theodor-Stern-Kai 7, D-6000, Frankfurt/M, FRG aut NATIONALLICENCE 773 0- Archives of Orthopaedic and Trauma Surgery Springer-Verlag 109/2(1990-02-01), 102-105 0936-8051 109:2<102 1990 109 402 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer