caa a22 4500 46573507X CHVBK 20180323111752.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00167062 doi (NATIONALLICENCE)springer-10.1007/BF00167062 Sensitization of C6 glioma to carboplatin cytotoxicity by hyperthermia and thymidine [Elektronische Daten] [Justin Cohen, H. Robins, Manucher Javid] Summary: Thymidine (a nucleoside metabolite) and 41.8° C hyperthermia were used to sensitize C6 glioma cells to carboplatin cytotoxicity in vitro. Clinically achievable thymidine concentrations (0, 200, 400, or 1000 µg/ml × 24 hours) significantly enhanced carboplatin killing. Clinically achievable hyperthermia exposures (40.5 or 41.8° C x 1 hour) also enhanced carboplatin killing; 41.8° C was more effective than was 40.5° C. Thymidine and 41.8°C hyperthermia together enhanced carboplatin killing significantly more than did the thymidine-carboplatin or hyperthermia-carboplatin combinations. These results illustrate the concept of ‘combination chemosensitization' for simultaneously addressing the divergent drug resistance mechanisms of malignant gliomas. Kluwer Academic Publishers, 1990 glioma nationallicence hyperthermia nationallicence carboplatin nationallicence thymidine nationallicence Cohen Justin Departments of Human Oncology and of Medicine, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut Robins H. Departments of Human Oncology and of Medicine, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut Javid Manucher Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/1(1990-08-01), 1-8 0167-594X 9:1<1 1990 9 11060 https://doi.org/10.1007/BF00167062 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00167062 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cohen Justin Departments of Human Oncology and of Medicine, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Robins H. Departments of Human Oncology and of Medicine, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut NATIONALLICENCE 700 1- Javid Manucher Department of Neurological Surgery, University of Wisconsin Hospital and Clinics, 53792, Madison, WI, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/1(1990-08-01), 1-8 0167-594X 9:1<1 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer