caa a22 4500 46573510X CHVBK 20180323111752.0 cr unu---uuuuu 170327e19900801xx s 000 0 eng 10.1007/BF00167064 doi (NATIONALLICENCE)springer-10.1007/BF00167064 Relationship between of blood flow, glucose metabolism, protein synthesis, glucose and ATP content in experimentally-induced glioma (RG12.2) of rat brain [Elektronische Daten] [G. Mies, W. Paschen, G. Ebhardt, K. Hossmann] Summary: In experimental RGl 2.2 glioma of rat brain, local blood flow, glucose utilization, protein synthesis, glucose and ATP content were measured by means of triple tracer autoradiography and bioluminescence technique, respectively, to determine hemodynamic and metabolic thresholds for local tumor energy failure. Perfusion thresholds were estimated at tumor blood flow values of 69.0 ± 0.1 ml/100 g/min (estimate ± standard error) and of 69 ± 7.1 ml/100 g/min for the beginning of the decline in regional ATP and glucose content, respectively. Metabolic thresholds were derived at tumor glucose utilization values of 70.6 ± 8.3 µ mol/100 g/min for reduced protein synthesis, of 55.0 ± 0.2 µmol/100 g/min for the decrease in glucose content, and 34.7 ± 4.7 µmol/100 g/min for decline in ATP content. Our results suggest that blood flow limits glucose supply to tumor tissue at much higher flow rates than in normal brain which, in turn, is associated with a decrease in tumor glucose utilization. A reduction and not an increase in tumor glucose availability could be a more appropriate strategy for the induction of energy failure in tumors. Kluwer Academic Publishers, 1990 brain tumor nationallicence triple tracer autoradiography nationallicence blood flow nationallicence glucose metabolism nationallicence protein synthesis nationallicence energy state nationallicence thresholds nationallicence Mies G. Sektion Neuropathologie der Krankenanstalten Köln, Max-Planck-Institut für neurologische Forschung Abteilung für experimentelle Neurologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut Paschen W. Sektion Neuropathologie der Krankenanstalten Köln, Max-Planck-Institut für neurologische Forschung Abteilung für experimentelle Neurologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut Ebhardt G. Sektion Neuropathologie der Krankenanstalten Köln, Institut für Pathologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut Hossmann K. Sektion Neuropathologie der Krankenanstalten Köln, Max-Planck-Institut für neurologische Forschung Abteilung für experimentelle Neurologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/1(1990-08-01), 17-28 0167-594X 9:1<17 1990 9 11060 https://doi.org/10.1007/BF00167064 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00167064 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mies G. Sektion Neuropathologie der Krankenanstalten Köln, Max-Planck-Institut für neurologische Forschung Abteilung für experimentelle Neurologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut NATIONALLICENCE 700 1- Paschen W. Sektion Neuropathologie der Krankenanstalten Köln, Max-Planck-Institut für neurologische Forschung Abteilung für experimentelle Neurologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut NATIONALLICENCE 700 1- Ebhardt G. Sektion Neuropathologie der Krankenanstalten Köln, Institut für Pathologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut NATIONALLICENCE 700 1- Hossmann K. Sektion Neuropathologie der Krankenanstalten Köln, Max-Planck-Institut für neurologische Forschung Abteilung für experimentelle Neurologie, Merheim Ostmerheimer Str. 200, D-5000, Köln, FRG aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/1(1990-08-01), 17-28 0167-594X 9:1<17 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer