caa a22 4500 465735193 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02341158 doi (NATIONALLICENCE)springer-10.1007/BF02341158 Longterm meningeal involvement as the only clinical manifestation of low grade malignant non-Hodgkin's lymphoma [Elektronische Daten] [J. Heimans, P. Wijermans, C. Polman, P. Huijgens, G. Ossenkoppele, G. van Kamp] Summary: We present the case of a 56-year old man who developed -at the age of 46-paraesthesia and numbness in the perianal region, the feet and lower legs accompanied by the presence of B-lymphocytes in the cerebrospinal fluid (CSF). Despite intensive work-up an explanation was not found until he developed hepato-splenomegaly ten years after the initial symptoms. Haematologic evaluation at that time disclosed a low-grade malignant B-cell lymphoma. Repeated CSF examination revealed 31 leukocytes/mm3, of which were mainly lymphocytes. These proved to be B-lymphocytes of monoclonal origin. These findings suggest that a leptomeningeal localisation of a low-grade malignant lymphoma had been present for ten years before systemic manifestation of the disease. Kluwer Academic Publishers, 1990 low-grade non-Hodgkin's lymphoma nationallicence leptomeningeal involvement nationallicence Heimans J. Department of Neurology, Free University Hospital, P.O. Box 2057, 1007 MB, Amsterdam, The Netherlands aut Wijermans P. Department of Haematology, Free University Hospital, Amsterdam, The Netherlands aut Polman C. Department of Neurology, Free University Hospital, P.O. Box 2057, 1007 MB, Amsterdam, The Netherlands aut Huijgens P. Department of Haematology, Free University Hospital, Amsterdam, The Netherlands aut Ossenkoppele G. Department of Haematology, Free University Hospital, Amsterdam, The Netherlands aut van Kamp G. Central Laboratory, Free University Hospital, Amsterdam, The Netherlands aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 275-277 0167-594X 9:3<275 1990 9 11060 https://doi.org/10.1007/BF02341158 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02341158 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Heimans J. Department of Neurology, Free University Hospital, P.O. Box 2057, 1007 MB, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Wijermans P. Department of Haematology, Free University Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Polman C. Department of Neurology, Free University Hospital, P.O. Box 2057, 1007 MB, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Huijgens P. Department of Haematology, Free University Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Ossenkoppele G. Department of Haematology, Free University Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van Kamp G. Central Laboratory, Free University Hospital, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 275-277 0167-594X 9:3<275 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer