caa a22 4500 465735207 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02341153 doi (NATIONALLICENCE)springer-10.1007/BF02341153 Leptomeningeal metastases: Comparison of clinical features and laboratory data of solid tumors, lymphomas and leukemias [Elektronische Daten] [Jerry Kaplan, Trevor DeSouza, Arthur Farkash, Bronislava Shafran, Daniel Pack, Faroog Rehman, Joachim Fuks, Russell Portenoy] We reviewed 63 cases of cytologically confirmed leptomeningeal metastases (LM). 31 (49%) had solid tumors 17 (27%) had leukemia and 15 (24%) had lymphoma. The most common presenting symptom was pain (76%) with radicular discomfort (58%), headache (32%), neck or back pain (17%). The predominant neurological signs were mental status abnormalities (49%), weakness (47%), seizures (14%). The mode of presentation varied with tumor type. Patients with leukemia (18%) and lymphoma (13%) tended to present frequently with LM without systemic involvement, or during periods of apparent remission (leukemia 35%, lymphoma 27%), while patients with solid tumors had established systemic metastases (90%) at time of presentation. Laboratory studies did not vary among the groups. 71% had positive cytology on the first lumbar puncture (LP) and only 8% required more than 2 LPs. The cell count was a poor predictor of positive cytology as 29% of LP's with positive cytology and 36% of all LP's had less than 4 cells/mm. We conclude that 1) LM presents with pain and seizures more frequently than has been previously recognized; 2) LM is frequently the mode of presentation in patients with leukemia and lymphoma and; 3) cytology is positive frequently in CSF specimens with normal cell counts and chemistries. Kluwer Academic Publishers, 1990 leptomeningeal metastasis nationallicence solid tumors nationallicence leukemias nationallicence lymphomas nationallicence lumbar puncture nationallicence cytology nationallicence Kaplan Jerry Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut DeSouza Trevor Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut Farkash Arthur Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut Shafran Bronislava Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut Pack Daniel Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut Rehman Faroog Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut Fuks Joachim The Department of Oncology, Albert Einstein College of Medicine, Bronx, New York aut Portenoy Russell Memorial Sloan Kettering Cancer Center New York, New York, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 225-229 0167-594X 9:3<225 1990 9 11060 https://doi.org/10.1007/BF02341153 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02341153 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kaplan Jerry Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut NATIONALLICENCE 700 1- DeSouza Trevor Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut NATIONALLICENCE 700 1- Farkash Arthur Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut NATIONALLICENCE 700 1- Shafran Bronislava Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut NATIONALLICENCE 700 1- Pack Daniel Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut NATIONALLICENCE 700 1- Rehman Faroog Department of Neurology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, 10461, Bronx, New York, USA aut NATIONALLICENCE 700 1- Fuks Joachim The Department of Oncology, Albert Einstein College of Medicine, Bronx, New York aut NATIONALLICENCE 700 1- Portenoy Russell Memorial Sloan Kettering Cancer Center New York, New York, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 225-229 0167-594X 9:3<225 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer