caa a22 4500 465735274 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02341155 doi (NATIONALLICENCE)springer-10.1007/BF02341155 High-dose multi-agent chemotherapy followed by bone marrow ‘rescue' for malignant astrocytomas of childhood and adolescence [Elektronische Daten] [Jonathan Finlay, Charles August, Roger Packer, Robert Zimmerman, Leslie Sutton, Arno Freid, Lucy Rorke, Eliel Bayever, Naynesh Kamani, Eric Kramer, Bruce Cohen, Beth Sturgill, James Nachman, Sarah Strandjord, Patrick Turski, Sharon Frierdich, Richard Steeves, Manucher Javid] Between April 1986 and March 1989, ten patients under 21 years of age with histologically confirmed malignant astrocytoma, received marrow-ablative chemotherapy with either thiotepa and Etoposide (five patients) or thiotepa, Etoposide and BCNU (five patients), followed by bone marrow ‘rescue'. Nine patients had glioblastoma multiforme (GBM), and one patient had an intrinsic brain stem anaplastic astrocytoma (AA). Seven patients were treated for recurrent tumor. Two patients who developed GBM as second malignancies were treated directly following surgical resection. One patient had received irradiation only for recently diagnosed cervical spinal cord GBM. Thiotepa was administered at a total dose of 600-900 mg/M2 over three days, Etoposide was administered at a total dose of 1500 mg/M2 over three days, and BCNU was administered at a total dose of 600 mg/M2 over four days. Non-hematopoietic toxicities have been mainly transient, predictable and acceptable, consisting of oropharyngeal mucositis, cutaneous hyperpigmentation, erythema and desquamation. Four patients achieved complete responses (CR), as determined by radiographic evaluation (CT and/or MRI) on day 28 post-marrow infusion. The mean remission duration of those with CR is 290 + days; two patients presently remain in remission. Two patients achieved partial responses (PR, greater than 50% tumor shrinkage) by day 28 post-marrow infusion; both developed disease progression, at day 61 and 94 post-marrow infusion, respectively. One patient, with a brain stem AA, had stable disease maintained for 13 months post-marrow infusion. With a total (CR + PR) response rate of 60%, these regimens merit evaluation in broader categories of recurrent brain tumor patients, as well as in patients with newly-diagnosed GBM. Kluwer Academic Publishers, 1990 malignant astrocytoma nationallicence chemotherapy nationallicence bone marrow rescue nationallicence Finlay Jonathan The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut August Charles The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Packer Roger The Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Zimmerman Robert The Division of Neuroradiology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Sutton Leslie The Division of Neurosurgery, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Freid Arno The Division of Neurosurgery, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Rorke Lucy The Division of Neuropathology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Bayever Eliel The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Kamani Naynesh The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Kramer Eric The Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Cohen Bruce The Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Sturgill Beth The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut Nachman James Division of Oncology, Wyler Children's Hospital, University of Chicago Medical Center, Chicago, IL, USA aut Strandjord Sarah Division of Pediatric Oncology, University of Nebraska, Omaha, NE, USA aut Turski Patrick Department of Radiology, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut Frierdich Sharon Department of Pediatrics, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut Steeves Richard Department of Radiation Oncology, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut Javid Manucher Department of Neurosurgery, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 239-248 0167-594X 9:3<239 1990 9 11060 https://doi.org/10.1007/BF02341155 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02341155 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Finlay Jonathan The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- August Charles The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Packer Roger The Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Zimmerman Robert The Division of Neuroradiology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Sutton Leslie The Division of Neurosurgery, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Freid Arno The Division of Neurosurgery, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Rorke Lucy The Division of Neuropathology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Bayever Eliel The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Kamani Naynesh The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Kramer Eric The Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Cohen Bruce The Division of Neurology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Sturgill Beth The Division of Oncology and Bone Marrow Trasplantation, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Nachman James Division of Oncology, Wyler Children's Hospital, University of Chicago Medical Center, Chicago, IL, USA aut NATIONALLICENCE 700 1- Strandjord Sarah Division of Pediatric Oncology, University of Nebraska, Omaha, NE, USA aut NATIONALLICENCE 700 1- Turski Patrick Department of Radiology, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut NATIONALLICENCE 700 1- Frierdich Sharon Department of Pediatrics, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut NATIONALLICENCE 700 1- Steeves Richard Department of Radiation Oncology, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut NATIONALLICENCE 700 1- Javid Manucher Department of Neurosurgery, The University of Wisconsin Center for Health Sciences, Madison, WI, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 239-248 0167-594X 9:3<239 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer