caa a22 4500 465735282 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901201xx s 000 0 eng 10.1007/BF02341156 doi (NATIONALLICENCE)springer-10.1007/BF02341156 Cisplatin induced neuropathy: Central, peripheral and autonomic nerve involvement [Elektronische Daten] [Willem Boogerd, Wim ten Bokkel Huinink, Otilia Dalesio, Walter Hoppenbrouwers, J. van der Sande] Summary: A prospective study was performed in patients treated with cisplatin to evaluate the occurrence and degree of central, peripheral and autonomic neuropathy and to determine the most accurate method to study this neuropathy. Twelve patients were examined before, during and after treatment. Evaluation included neurologic examination, conventional nerve conduction studies of the median and peroneal nerves and short latency somatosensory evoked potentials (SSER) after median and tibial nerve stimulation. Valsalva maneuvers before and during treatment were performed in 11 patients. Symptoms of peripheral neuropathy paralleled clinical signs. Conventional nerve conduction studies did not seem to be more accurate than clinical examination in determining peripheral neuropathy. SSER appeared to be the most sensitive method for the detection of peripheral nerve impairment. A slowing of central conduction velocity occurred after cumulative doses of 200-400 mg/m2 as measured by SSER. In two patients also some involvement of the autonomic nerves was suggested. Kluwer Academic Publishers, 1990 cisplatin nationallicence central neurotoxicity nationallicence peripheral neurotoxicity nationallicence autonomic neurotoxicity nationallicence Boogerd Willem The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut ten Bokkel Huinink Wim The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut Dalesio Otilia The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut Hoppenbrouwers Walter Division of Clinical Neurophysiology of the Municipal Hospital Slotervaart, Amsterdam, The Netherlands aut van der Sande J. The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 255-263 0167-594X 9:3<255 1990 9 11060 https://doi.org/10.1007/BF02341156 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02341156 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boogerd Willem The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut NATIONALLICENCE 700 1- ten Bokkel Huinink Wim The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut NATIONALLICENCE 700 1- Dalesio Otilia The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut NATIONALLICENCE 700 1- Hoppenbrouwers Walter Division of Clinical Neurophysiology of the Municipal Hospital Slotervaart, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- van der Sande J. The Clinical Division of the Netherlands Cancer Institute (Antonie van Leeuwenhoekziekenhuis), The Netherlands aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/3(1990-12-01), 255-263 0167-594X 9:3<255 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer