caa a22 4500 465735290 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02427831 doi (NATIONALLICENCE)springer-10.1007/BF02427831 Aldehyde dehydrogenase activity in xenografted human brain tumor in nude mice. Preliminary results in human glioma biopsies [Elektronische Daten] [Véronique Quemener, Jacques-Philippe Moulinoux, Christian Martin, Françoise Darcel, Yvon Guegan, Jean Faivre, Gerald Quash] ALDH activity measured fluorimetrically using a high concentration of aliphatic aldehyde as substrate was studied in human glioblastomas grafted in nude mice. Compared with normal brain, ALDH activity is significantly increased in malignant glioma tissue, especially in the cytosolic subcellular fraction. Correlatively, in comparison with normal brain tissue, MDA levels were significantly reduced in whole homogenates and in cytosolic fractions of xenografted glioblastoma tissue. Preliminary results concerning human malignant glioma biopsies are in good agreement with our experimental data. In view of previous works, these results suggest a relationship between alterations in ALDH iso-enzymes activities and cytosolic aldehyde concentrations with respect to normal or tumoral cell growth. Kluwer Academic Publishers, 1990 aldehyde dehydrogenase (ALDH) nationallicence malondialdehyde (MDA) nationallicence malignant glioma nationallicence brain tumors nationallicence subcellular fractionation nationallicence Quemener Véronique Department of Cell Biology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut Moulinoux Jacques-Philippe Department of Cell Biology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut Martin Christian Department of Cell Biology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut Darcel Françoise Department of Neuropathology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut Guegan Yvon Department of Neurosurgery, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut Faivre Jean I. N. S. E. R. M. U-51, Unité de Virologie Fondamentale et Appliquée, 2, place du Pr Joseph Renaut, 69371, Lyon-Cedex, France aut Quash Gerald aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 115-123 0167-594X 9:2<115 1990 9 11060 https://doi.org/10.1007/BF02427831 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02427831 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Quemener Véronique Department of Cell Biology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut NATIONALLICENCE 700 1- Moulinoux Jacques-Philippe Department of Cell Biology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut NATIONALLICENCE 700 1- Martin Christian Department of Cell Biology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut NATIONALLICENCE 700 1- Darcel Françoise Department of Neuropathology, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut NATIONALLICENCE 700 1- Guegan Yvon Department of Neurosurgery, Centre Hospitalier Universitaire de Rennes, 2, avenue du Professeur Léon Bernard, 35043, Rennes-Cedex, France aut NATIONALLICENCE 700 1- Faivre Jean I. N. S. E. R. M. U-51, Unité de Virologie Fondamentale et Appliquée, 2, place du Pr Joseph Renaut, 69371, Lyon-Cedex, France aut NATIONALLICENCE 700 1- Quash Gerald aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 115-123 0167-594X 9:2<115 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer