caa a22 4500 465735339 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02427833 doi (NATIONALLICENCE)springer-10.1007/BF02427833 Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate [Elektronische Daten] [Rafael Tamargo, Kam Leong, Henry Brem] Summary: Malignant gliomas are difficult to treat systemically because of exclusion of many chemotherapeutic agents by the blood brain barrier. Furthermore, as opposed to other neoplasms, malignant gliomas recur locally, at the site of original presentation. These tumors are remarkably vascular and hence may be more dependent on angiogenesis for continued growth than other tumors. The inhibition of tumor angiogenesis can control tumor growth by preventing the exponential vascular growth phase. We report the inhibition of the growth of the 9L glioma by the localized, controlled release of known angiogenesis inhibitors administered in a biodegradable polyanhydride polymer matrix. In the presence of heparin and cortisone and of cortisone alone there was a 4.5- and 2.3-fold reduction, respectively, in the growth of the 9L glioma. We compared these results to the inhibition of tumor neovascularization in the rabbit cornea by the localized delivery of the same agents. In the rabbit cornea model, the local release of heparin and cortisone and of cortisone alone resulted in a 2.5- and 2.0-fold reduction, respectively, in the angiogenesis response evoked by the VX2 carcinoma. This study introduces two new potential therapeutic modalities for the treatment of malignant gliomas: the use of the combination of heparin and cortisone as antineoplastic agents and the use of polymeric carriers for the local delivery of such agents in the central nervous system. Kluwer Academic Publishers, 1990 brain tumors nationallicence heparin nationallicence cortisone nationallicence controlled-release polymers nationallicence drug delivery nationallicence angiogenesis nationallicence Tamargo Rafael Departments of Neurological Surgery, The Johns Hopkins Unversity School of Medicine, 21205, Baltimore, MD, USA aut Leong Kam Biomedical Engineering, The Johns Hopkins Unversity School of Medicine, 21205, Baltimore, MD, USA aut Brem Henry Departments of Neurological Surgery, The Johns Hopkins Unversity School of Medicine, 21205, Baltimore, MD, USA aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 131-138 0167-594X 9:2<131 1990 9 11060 https://doi.org/10.1007/BF02427833 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02427833 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tamargo Rafael Departments of Neurological Surgery, The Johns Hopkins Unversity School of Medicine, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Leong Kam Biomedical Engineering, The Johns Hopkins Unversity School of Medicine, 21205, Baltimore, MD, USA aut NATIONALLICENCE 700 1- Brem Henry Departments of Neurological Surgery, The Johns Hopkins Unversity School of Medicine, 21205, Baltimore, MD, USA aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 131-138 0167-594X 9:2<131 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer