caa a22 4500 465735363 CHVBK 20180323111753.0 cr unu---uuuuu 170327e19901001xx s 000 0 eng 10.1007/BF02427836 doi (NATIONALLICENCE)springer-10.1007/BF02427836 Modification of the 8 drugs in 1 day regimen: feasibility of substitution of other agents [Elektronische Daten] [Ka Chan, Christopher Fryer, Paul Steinbok] Summary: Six children (ages 2 to 14 years) with recurrent or poor risk primary brain tumors were treated with the 's8 drugs in 1 day' chemotherapy regimen. As renal function deteriorated (median after five cycles), carboplatin was substituted in place of cisplatin at a median dose of 300 mg/m2 as a one hour infusion at hour three. Four patients also had their lomustine deleted and replaced by etoposide 100 mg/m2 at hour four. Compared to earlier cycles of chemotherapy, there was a moderate increase in transfusion requirement (especially platelets) but the incidences of fever and neutropenia were unchanged. Glomerular function as measured by nuclear glomerular filtration rate (GFR) remained unchanged or improved at the end of therapy. The severity of nausea and vomiting after substitution was markedly improved. Four of the six patients are still in complete remission 19 to 41 months after diagnosis or recurrence. It is feasible to substitute carboplatin and etoposide into the ‘8 drugs in 1 day' regimen when extramedullary toxicity is found. Kluwer Academic Publishers, 1990 8 in 1 chemotherapy nationallicence carboplatin nationallicence etoposide nationallicence myelosuppression nationallicence Chan Ka The Department of Pediatrics, University of British Columbia & B. C. Children's Hospital Vancouver, British Columbia, Canada aut Fryer Christopher The Department of Pediatrics, University of British Columbia & B. C. Children's Hospital Vancouver, British Columbia, Canada aut Steinbok Paul The Department of Pediatrics, University of British Columbia & B. C. Children's Hospital Vancouver, British Columbia, Canada aut Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 153-157 0167-594X 9:2<153 1990 9 11060 https://doi.org/10.1007/BF02427836 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02427836 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chan Ka The Department of Pediatrics, University of British Columbia & B. C. Children's Hospital Vancouver, British Columbia, Canada aut NATIONALLICENCE 700 1- Fryer Christopher The Department of Pediatrics, University of British Columbia & B. C. Children's Hospital Vancouver, British Columbia, Canada aut NATIONALLICENCE 700 1- Steinbok Paul The Department of Pediatrics, University of British Columbia & B. C. Children's Hospital Vancouver, British Columbia, Canada aut NATIONALLICENCE 773 0- Journal of Neuro-Oncology Kluwer Academic Publishers 9/2(1990-10-01), 153-157 0167-594X 9:2<153 1990 9 11060 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer